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题名: Theory of DNA melting based on the Peyrard-Bishop model
作者: Zhang, YL ;  Zheng, WM ;  Liu, JX ;  Chen, YZ
刊名: PHYSICAL REVIEW E
出版日期: 1997
卷号: 56, 期号:6, 页码:7100-7115
关键词: STATISTICAL-MECHANICS ;  NONLINEAR MODEL ;  THERMAL-DENATURATION ;  PHASE-TRANSITION ;  DYNAMICS
学科分类: Physics
通讯作者: Zhang, YL , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
部门归属: Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China; Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA
英文摘要: The DNA melting based on the Peyrard-Bishop (PB) model is systematically investigated. Our study on the eigenvalues and eigenvectors of the transfer integral equation for the original PB model points out that the eigenvectors are composed of two kinds: discrete bound states that constitute the internal states of a DNA molecule and the continuous unbound states that represent its dissociated states. Another process controlling the melting of DNA-the dissociation equilibrium between duplex and single-stranded DNAs-is introduced, which leads to an extended model applicable for a realistic DNA chain with a finite number of base pairs. Based on the expansion of kernels, the calculations of the thermodynamic quantities of the system are reduced to multiplication of matrix series. Calculations on model block DNAs show the method is much more efficient than molecular dynamic simulation and has enough high precision to handle the melting of a natural DNA with arbitrary sequence. The discreteness effect and nonlinear effect of the model are discussed based on the Gaussian model. Rigorous melting curves for periodic DNA with two and three base pairs in a unit cell and boundary effects are presented by the transfer integral approach.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000071043500107
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/12403
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Zhang, YL,Zheng, WM,Liu, JX,et al. Theory of DNA melting based on the Peyrard-Bishop model[J]. PHYSICAL REVIEW E,1997,56(6):7100-7115.
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