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题名: Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?
作者: Zhou, HJ ;  Zhang, Y
刊名: JOURNAL OF CHEMICAL PHYSICS
出版日期: 2001
卷号: 114, 期号:19, 页码:8694-8700
关键词: DOUBLE-STRANDED DNA ;  RNA SECONDARY STRUCTURE ;  SUPERCOILED DNA ;  SINGLE-MOLECULE ;  ENTROPIC ELASTICITY ;  MECHANICS ;  MODEL ;  POLYMERASE
学科分类: Physics
通讯作者: Zhou, HJ , Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany.
部门归属: Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: Force-induced structural transitions both in relatively random and in designed single-stranded DNA (ssDNA) chains are studied theoretically. At high salt conditions, ssDNA forms compacted hairpin patterns stabilized by base pairing and base-pair stacking interactions, and a threshold external force is needed to pull the hairpinned structure into a random coiled one. The base-pair stacking interaction in the ssDNA chain makes this hairpin-coil conversion a discontinuous (first-order) phase transition process characterized by a force plateau in the force-extension curve, while lowering this potential below some critical level turns this transition into continuous (second-order) type, no matter how strong the base-pairing interaction is. The phase diagram (including hairpin-I, -II, and random coil) is discussed as a function of stacking potential and external force. These results are in quantitative agreement with recent experimental observations of different ssDNA sequences, and they reveal the necessity to consider the base-pair stacking interactions in order to understand the structural formation of RNA, a polymer designed by nature itself. The theoretical method used may be extended to study the long-range interaction along double-stranded DNA caused by the topological constraint of fixed linking number. (C) 2001 American Institute of Physics.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000168440400053
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/12751
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Zhou, HJ,Zhang, Y. Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?[J]. JOURNAL OF CHEMICAL PHYSICS,2001,114(19):8694-8700.
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