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题名: Difference between "proteinlike" and "nonproteinlike" heteropolymers
作者: Chen, H ;  Zhou, X ;  Ou-Yang, ZC
刊名: PHYSICAL REVIEW E
出版日期: 2001
卷号: 63, 期号:3, 页码:-
关键词: SIMPLE-MODEL ;  SEQUENCES ;  ENUMERATION ;  TRANSITION ;  SIMULATION ;  STABILITY ;  DYNAMICS ;  FOLD
学科分类: Physics
通讯作者: Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
部门归属: Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: Based on a simple two-dimensional (2D) hydrophobic-polar (H-P) lattice model, properties of amino acid chains are studied by enumeration and Monte-Carlo simulation methods. Among them some chains with Large average energy gap ((E-g) over bar) are thought to be "proteinlike" while the others are "nonproteinlike." The large (E-g) over bar between the low excited conformations and the native conformation guarantees not only the thermodynamic stability of protein but also its fast-folding property. The phase transition from molten globule to the native conformation for the "proteinlike" polymer is found to be of first order, while that for the ''nonproteinlike'' polymer is not. Some properties of chains as a function of (E-g) over bar shows that the transition from "nonproteinlike" to "proteinlike" heteropolymers is continuous. The simulation of folding at different temperature indicates that the main reason why some polymers fold slowly to its native conformation is their low folding temperature which makes the effective energy barrier (E-b/T-f) much higher than "proteinlike" chains.
收录类别: SCI
WOS记录号: WOS:000167623900068
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/12807
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Chen, H,Zhou, X,Ou-Yang, ZC. Difference between "proteinlike" and "nonproteinlike" heteropolymers[J]. PHYSICAL REVIEW E,2001,63(3):-.
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