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Difference between "proteinlike" and "nonproteinlike" heteropolymers
Chen, H; Zhou, X; Ou-Yang, ZC; Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
2001
发表期刊PHYSICAL REVIEW E
ISSN1063-651X
卷号63期号:3页码:-
摘要Based on a simple two-dimensional (2D) hydrophobic-polar (H-P) lattice model, properties of amino acid chains are studied by enumeration and Monte-Carlo simulation methods. Among them some chains with Large average energy gap ((E-g) over bar) are thought to be "proteinlike" while the others are "nonproteinlike." The large (E-g) over bar between the low excited conformations and the native conformation guarantees not only the thermodynamic stability of protein but also its fast-folding property. The phase transition from molten globule to the native conformation for the "proteinlike" polymer is found to be of first order, while that for the ''nonproteinlike'' polymer is not. Some properties of chains as a function of (E-g) over bar shows that the transition from "nonproteinlike" to "proteinlike" heteropolymers is continuous. The simulation of folding at different temperature indicates that the main reason why some polymers fold slowly to its native conformation is their low folding temperature which makes the effective energy barrier (E-b/T-f) much higher than "proteinlike" chains.
部门归属Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Simple-model Sequences Enumeration Transition Simulation Stability Dynamics Fold
学科领域Physics
收录类别SCI
WOS记录号WOS:000167623900068
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/12807
专题理论物理所1978-2010年知识产出
通讯作者Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
推荐引用方式
GB/T 7714
Chen, H,Zhou, X,Ou-Yang, ZC,et al. Difference between "proteinlike" and "nonproteinlike" heteropolymers[J]. PHYSICAL REVIEW E,2001,63(3):-.
APA Chen, H,Zhou, X,Ou-Yang, ZC,&Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2001).Difference between "proteinlike" and "nonproteinlike" heteropolymers.PHYSICAL REVIEW E,63(3),-.
MLA Chen, H,et al."Difference between "proteinlike" and "nonproteinlike" heteropolymers".PHYSICAL REVIEW E 63.3(2001):-.
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