ITP OpenIR  > 理论物理所1978-2010年知识产出
Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae
Hu, R; Wang, B; Hu, R , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 10080, Peoples R China.
2001
发表期刊PHYSICA A
ISSN0378-4371
卷号290期号:40972页码:464-474
摘要Finding out statistically significant words in DNA and protein sequences forms the basis for many genetic studies. By applying the maximal entropy principle, we give one systematic way to study the nonrandom occurrence of words in DNA or protein sequences. Through comparison with experimental results, it was shown that patterns of regulatory binding sites in Saccharomyces cerevisiae (yeast) genomes tend to occur significantly in the promoter regions. We studied two correlated gene families of yeast. The method successfully extracts the binding sites verified by experiments in each family. Many putative regulatory sites in the upstream regions are proposed. The study also suggested that some regulatory sites are active in both directions, while others show directional preference. (C) 2001 Elsevier Science B.V. All rights reserved.
部门归属Acad Sinica, Inst Theoret Phys, Beijing 10080, Peoples R China; Univ Sci & Technol China, Dept Modern Phys, Anhui, Peoples R China
关键词Dna-sequences Nucleotide-sequences Genome Genes
学科领域Physics
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收录类别SCI
WOS记录号WOS:000166891700011
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/12814
专题理论物理所1978-2010年知识产出
通讯作者Hu, R , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 10080, Peoples R China.
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GB/T 7714
Hu, R,Wang, B,Hu, R , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 10080, Peoples R China.. Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae[J]. PHYSICA A,2001,290(40972):464-474.
APA Hu, R,Wang, B,&Hu, R , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 10080, Peoples R China..(2001).Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae.PHYSICA A,290(40972),464-474.
MLA Hu, R,et al."Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae".PHYSICA A 290.40972(2001):464-474.
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