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题名: Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae
作者: Hu, R ;  Wang, B
刊名: PHYSICA A
出版日期: 2001
卷号: 290, 期号:40972, 页码:464-474
关键词: DNA-SEQUENCES ;  NUCLEOTIDE-SEQUENCES ;  GENOME ;  GENES
学科分类: Physics
通讯作者: Hu, R , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 10080, Peoples R China.
部门归属: Acad Sinica, Inst Theoret Phys, Beijing 10080, Peoples R China; Univ Sci & Technol China, Dept Modern Phys, Anhui, Peoples R China
英文摘要: Finding out statistically significant words in DNA and protein sequences forms the basis for many genetic studies. By applying the maximal entropy principle, we give one systematic way to study the nonrandom occurrence of words in DNA or protein sequences. Through comparison with experimental results, it was shown that patterns of regulatory binding sites in Saccharomyces cerevisiae (yeast) genomes tend to occur significantly in the promoter regions. We studied two correlated gene families of yeast. The method successfully extracts the binding sites verified by experiments in each family. Many putative regulatory sites in the upstream regions are proposed. The study also suggested that some regulatory sites are active in both directions, while others show directional preference. (C) 2001 Elsevier Science B.V. All rights reserved.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000166891700011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/12814
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Hu, R,Wang, B. Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae[J]. PHYSICA A,2001,290(40972):464-474.
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