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Zhou, HJ; Zhang, Y; Ou-Yang, ZC; Zhou, HJ , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments
Source PublicationPHYSICAL REVIEW E
KeywordSupercoiled Dna Entropic Elasticity Stretching Dna Model Extension Topoisomerases Fluctuations Stiffness Filaments Mechanism
AbstractThis paper aims at a comprehensive understanding of the novel elastic property of double-stranded DNA (dsDNA) discovered very recently through single-molecule manipulation techniques. A general elastic model for double-stranded biopolymers is proposed, and a structural parameter called the folding angle cp is introduced to characterize their deformations. The mechanical property of long dsDNA molecules is then studied based on this model, where the base-stacking interactions between DNA adjacent nucleotide base pairs, the steric effects of base pairs, and the electrostatic interactions along DNA backbones are taken into account. Quantitative results are obtained by using a path integral method and excellent agreement between theory and the observations reported by five major experimental groups are attained. The strong intensity of the base stacking interactions ensures the structural stability of DNA, while the short-ranged nature of such interactions makes externally stimulated large structural fluctuations possible. The entropic elasticity, highly extensibility, and supercoiling property of DNA are all closely related to this account. The present work also suggests the possibility that negative torque can induce structural transitions in highly extended DNA from the right-handed B form to left-handed configurations similar to the Z-form configuration. Some formulas concerned with the application of path integral methods to polymeric systems are listed in the Appendixes.
2000
ISSN1063-651X
Volume62Issue:1Pages:1045-1058
Subject AreaPhysics
Indexed BySCI
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Cited Times:61[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/12949
CollectionSCI期刊论文
Corresponding AuthorZhou, HJ , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
Recommended Citation
GB/T 7714
Zhou, HJ,Zhang, Y,Ou-Yang, ZC,et al. Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments[J]. PHYSICAL REVIEW E,2000,62(1):1045-1058.
APA Zhou, HJ,Zhang, Y,Ou-Yang, ZC,&Zhou, HJ , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2000).Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments.PHYSICAL REVIEW E,62(1),1045-1058.
MLA Zhou, HJ,et al."Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments".PHYSICAL REVIEW E 62.1(2000):1045-1058.
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