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Monte Carlo implementation of supercoiled double-stranded DNA
Zhang, Y; Zhou, HJ; Ou-Yang, ZC; Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
2000
发表期刊BIOPHYSICAL JOURNAL
ISSN0006-3495
卷号78期号:4页码:1979-1987
摘要Metropolis Monte Carlo simulation is used to investigate the elasticity of torsionally stressed double-stranded DNA, in which twist and supercoiling are incorporated as a natural result of base-stacking interaction and backbone bending constrained by hydrogen bonds formed between DNA complementary nucleotide bases. Three evident regimes are found in extension versus torsion and force versus extension plots: a low-force regime in which over- and underwound molecules behave similarly under stretching; an intermediate-force regime in which chirality appears for negatively and positively supercoiled DNA and extension of underwound molecule is insensitive to the supercoiling degree of the polymer; and a large-force regime in which plectonemic DNA is fully converted to extended DNA and supercoiled DNA behaves quite like a torsionless molecule. The striking coincidence between theoretic calculations and recent experimental measurement of torsionally stretched DNA (Strick et al., Science. 271:1835, 1996; Biophys. J. 74:2016, 1998) strongly suggests that the interplay between base-stacking interaction and permanent hydrogen-bond constraint takes an important role in understanding the novel properties of elasticity of supercoiled DNA polymer.
部门归属Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China; Free Univ Berlin, Inst Theoret Phys, D-14195 Berlin, Germany; State Key Lab Sci & Engn Comp, Beijing 100080, Peoples R China; Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
关键词Elasticity Molecule Model Stiffness Mechanics Polymers
学科领域Physics
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收录类别SCI
WOS记录号WOS:000086349500029
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/12984
专题理论物理所SCI论文
通讯作者Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
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Zhang, Y,Zhou, HJ,Ou-Yang, ZC,et al. Monte Carlo implementation of supercoiled double-stranded DNA[J]. BIOPHYSICAL JOURNAL,2000,78(4):1979-1987.
APA Zhang, Y,Zhou, HJ,Ou-Yang, ZC,&Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2000).Monte Carlo implementation of supercoiled double-stranded DNA.BIOPHYSICAL JOURNAL,78(4),1979-1987.
MLA Zhang, Y,et al."Monte Carlo implementation of supercoiled double-stranded DNA".BIOPHYSICAL JOURNAL 78.4(2000):1979-1987.
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