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题名: Monte Carlo implementation of supercoiled double-stranded DNA
作者: Zhang, Y ;  Zhou, HJ ;  Ou-Yang, ZC
刊名: BIOPHYSICAL JOURNAL
出版日期: 2000
卷号: 78, 期号:4, 页码:1979-1987
关键词: ELASTICITY ;  MOLECULE ;  MODEL ;  STIFFNESS ;  MECHANICS ;  POLYMERS
学科分类: Physics
通讯作者: Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
部门归属: Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China; Free Univ Berlin, Inst Theoret Phys, D-14195 Berlin, Germany; State Key Lab Sci & Engn Comp, Beijing 100080, Peoples R China; Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
英文摘要: Metropolis Monte Carlo simulation is used to investigate the elasticity of torsionally stressed double-stranded DNA, in which twist and supercoiling are incorporated as a natural result of base-stacking interaction and backbone bending constrained by hydrogen bonds formed between DNA complementary nucleotide bases. Three evident regimes are found in extension versus torsion and force versus extension plots: a low-force regime in which over- and underwound molecules behave similarly under stretching; an intermediate-force regime in which chirality appears for negatively and positively supercoiled DNA and extension of underwound molecule is insensitive to the supercoiling degree of the polymer; and a large-force regime in which plectonemic DNA is fully converted to extended DNA and supercoiled DNA behaves quite like a torsionless molecule. The striking coincidence between theoretic calculations and recent experimental measurement of torsionally stretched DNA (Strick et al., Science. 271:1835, 1996; Biophys. J. 74:2016, 1998) strongly suggests that the interplay between base-stacking interaction and permanent hydrogen-bond constraint takes an important role in understanding the novel properties of elasticity of supercoiled DNA polymer.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000086349500029
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/12984
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Zhang, Y,Zhou, HJ,Ou-Yang, ZC. Monte Carlo implementation of supercoiled double-stranded DNA[J]. BIOPHYSICAL JOURNAL,2000,78(4):1979-1987.
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