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Zhang, Y; Zhou, HJ; Ou-Yang, ZC; Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
Monte Carlo implementation of supercoiled double-stranded DNA
Source PublicationBIOPHYSICAL JOURNAL
KeywordElasticity Molecule Model Stiffness Mechanics Polymers
AbstractMetropolis Monte Carlo simulation is used to investigate the elasticity of torsionally stressed double-stranded DNA, in which twist and supercoiling are incorporated as a natural result of base-stacking interaction and backbone bending constrained by hydrogen bonds formed between DNA complementary nucleotide bases. Three evident regimes are found in extension versus torsion and force versus extension plots: a low-force regime in which over- and underwound molecules behave similarly under stretching; an intermediate-force regime in which chirality appears for negatively and positively supercoiled DNA and extension of underwound molecule is insensitive to the supercoiling degree of the polymer; and a large-force regime in which plectonemic DNA is fully converted to extended DNA and supercoiled DNA behaves quite like a torsionless molecule. The striking coincidence between theoretic calculations and recent experimental measurement of torsionally stretched DNA (Strick et al., Science. 271:1835, 1996; Biophys. J. 74:2016, 1998) strongly suggests that the interplay between base-stacking interaction and permanent hydrogen-bond constraint takes an important role in understanding the novel properties of elasticity of supercoiled DNA polymer.
2000
ISSN0006-3495
Volume78Issue:4Pages:1979-1987
Subject AreaPhysics
Indexed BySCI
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Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/12984
CollectionSCI期刊论文
Corresponding AuthorZhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
Recommended Citation
GB/T 7714
Zhang, Y,Zhou, HJ,Ou-Yang, ZC,et al. Monte Carlo implementation of supercoiled double-stranded DNA[J]. BIOPHYSICAL JOURNAL,2000,78(4):1979-1987.
APA Zhang, Y,Zhou, HJ,Ou-Yang, ZC,&Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2000).Monte Carlo implementation of supercoiled double-stranded DNA.BIOPHYSICAL JOURNAL,78(4),1979-1987.
MLA Zhang, Y,et al."Monte Carlo implementation of supercoiled double-stranded DNA".BIOPHYSICAL JOURNAL 78.4(2000):1979-1987.
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