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题名: The elastic theory of a single DNA molecule
作者: Zhou, HJ ;  Zhang, Y ;  Ou-Yang, ZC
刊名: PRAMANA-JOURNAL OF PHYSICS
出版日期: 2003
卷号: 61, 期号:2, 页码:353-360
关键词: DOUBLE-STRANDED DNA ;  SUPERCOILED DNA ;  POLYMERASE ;  MECHANICS
学科分类: Physics
通讯作者: Zhou, HJ , Chinese Acad Sci, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
部门归属: Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China; Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany; Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
英文摘要: We study the elastic responses of double- (ds) and single-stranded (ss) DNA at external force fields. A double-strand-polymer elastic model is constructed and solved by path integral methods and Monte Carlo simulations to understand the entropic elasticity, cooperative extensibility, and supercoiling property of dsDNA. The good agreement with experiments indicates that short-ranged base-pair stacking interaction is crucial for the stability and the high deformability of dsDNA. Hairpin-coil transition in ssDNA is studied with generating function method. A threshold force is needed to pull the ssDNA hairpin patterns, stabilized by base pairing and base-pair stacking, into random coils. This phase transition is predicted to be of first order for stacking potential higher than some critical level, in accordance with experimental observations.
收录类别: SCI
原文出处: 查看原文
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/13254
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Zhou, HJ,Zhang, Y,Ou-Yang, ZC. The elastic theory of a single DNA molecule[J]. PRAMANA-JOURNAL OF PHYSICS,2003,61(2):353-360.
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