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题名: In-phase implies large likelihood for independent codon model: distinguishing coding from non-coding sequences
作者: Zheng, WM ;  Wu, F
刊名: JOURNAL OF THEORETICAL BIOLOGY
出版日期: 2003
卷号: 223, 期号:2, 页码:199-203
关键词: IDENTIFICATION ;  REGIONS
学科分类: Physics
通讯作者: Zheng, WM , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
部门归属: Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: It is proven that under the independent codon model, the likelihood of a DNA coding sequence read according to the correct frame is asymptotically larger than that read with an incorrect frame. Based on this proposition, a single set of probabilities of the codon usage is enough for discriminating the six frames of coding sequences under the independent codon model. The direct coding sequence of Escherichia coli genome is taken as an example to examine the codon independency by using the mutual information and chi(2) analysis. The contrast between the coding frame and the two offset frames is evident. A self-learning approach for generating training set is proposed to estimate probability parameters. (C) 2003 Elsevier Rience Ltd. All rights reserved.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000184078400006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/13257
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Zheng, WM,Wu, F. In-phase implies large likelihood for independent codon model: distinguishing coding from non-coding sequences[J]. JOURNAL OF THEORETICAL BIOLOGY,2003,223(2):199-203.
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