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Zheng, WM; Wu, F; Zheng, WM , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
In-phase implies large likelihood for independent codon model: distinguishing coding from non-coding sequences
Source PublicationJOURNAL OF THEORETICAL BIOLOGY
KeywordIdentification Regions
AbstractIt is proven that under the independent codon model, the likelihood of a DNA coding sequence read according to the correct frame is asymptotically larger than that read with an incorrect frame. Based on this proposition, a single set of probabilities of the codon usage is enough for discriminating the six frames of coding sequences under the independent codon model. The direct coding sequence of Escherichia coli genome is taken as an example to examine the codon independency by using the mutual information and chi(2) analysis. The contrast between the coding frame and the two offset frames is evident. A self-learning approach for generating training set is proposed to estimate probability parameters. (C) 2003 Elsevier Rience Ltd. All rights reserved.
2003
ISSN0022-5193
Volume223Issue:2Pages:199-203
Subject AreaPhysics
Indexed BySCI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/13257
Collection理论物理所科研产出_SCI论文
Corresponding AuthorZheng, WM , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
Recommended Citation
GB/T 7714
Zheng, WM,Wu, F,Zheng, WM , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.. In-phase implies large likelihood for independent codon model: distinguishing coding from non-coding sequences[J]. JOURNAL OF THEORETICAL BIOLOGY,2003,223(2):199-203.
APA Zheng, WM,Wu, F,&Zheng, WM , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2003).In-phase implies large likelihood for independent codon model: distinguishing coding from non-coding sequences.JOURNAL OF THEORETICAL BIOLOGY,223(2),199-203.
MLA Zheng, WM,et al."In-phase implies large likelihood for independent codon model: distinguishing coding from non-coding sequences".JOURNAL OF THEORETICAL BIOLOGY 223.2(2003):199-203.
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