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题名: Molecular phylogeny of coronaviruses including human SARS-CoV
作者: Gao, L ;  Qi, J ;  Wei, HB ;  Sun, YG ;  Hao, BL
刊名: CHINESE SCIENCE BULLETIN
出版日期: 2003
卷号: 48, 期号:12, 页码:1170-1174
关键词: ACUTE RESPIRATORY SYNDROME ;  SEQUENCE
学科分类: Physics
通讯作者: Hao, BL , Fudan Univ, T Life Res Ctr, Shanghai 200433, Peoples R China.
部门归属: Fudan Univ, T Life Res Ctr, Shanghai 200433, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China; Zhejiang Univ, Grad Sch, Hangzhou 310027, Peoples R China; Chinese Acad Sci, Beijing Genom Inst, Hangzhou Branch, Hangzhou 310008, Peoples R China
英文摘要: Phylogenetic tree of coronaviruses (CoVs) including the human SARS-associated virus is reconstructed from complete genomes by using our newly developed K-string composition approach. The relation of the human SARS-CoV to other coronaviruses, i.e. the rooting of the tree is suggested by choosing an appropriate outgroup. SARS-CoV makes a separate group closer but still distant from G2 (CoVs in mammalian host). The relation between different isolates of the human SARS virus is inferred by first constructing an ultrametric distance matrix from counting sequence variations in the genomes. The resulting tree is consistent with clinic relations between the SARS-CoV isolates. In addition to a larger variety of coronavirus genomes these results provide phylogenetic knowledge based on independent novel methodology as compared to recent phylogenetic studies on SARS-CoV.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000184249300002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/13280
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Gao, L,Qi, J,Wei, HB,et al. Molecular phylogeny of coronaviruses including human SARS-CoV[J]. CHINESE SCIENCE BULLETIN,2003,48(12):1170-1174.
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