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The elastic theory of a single DNA molecule
Ou-Yang, ZC; Zhou, H; Zhang, Y; Ou-Yang, ZC , Chinese Acad Sci, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
2003
发表期刊MODERN PHYSICS LETTERS B
ISSN0217-9849
卷号17期号:1页码:1-10
摘要We review our recent efforts in understanding the elastic properties of double-stranded (ds) and single-stranded (as) DNA macromolecules. A simple geometric model of dsDNA was constructed and solved by path integral methods. The good agreement with experiments on dsDNA's entropic elasticity, cooperative extensibility, and supercoiling property suggested that the short-ranged base-pair stacking interaction is crucial for the stability and the high deformability of dsDNA. For ssDNA at high ionic conditions, base-pairing and base-pair stacking interactions cause the polymer to fold into compact hairpin configurations. The force-induced hairpin-coil transition was studied with the generating function method. In accordance with experiment, this transition was found to be highly cooperative when the average stacking potential is higher than some critical level. At low ionic conditions, the electrostatic repulsive interaction along the ssDNA becomes dominant, and ssDNA can be regarded as model polyelectrolytes. Our MC simulation results suggested an exponential relation between external force and the total extension. This prediction was confirmed experimentally.
部门归属Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Double-stranded Dna Polynucleotide Chains Stacking Interactions Transitions Polymerase
学科领域Physics
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收录类别SCI
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/13374
专题理论物理所1978-2010年知识产出
通讯作者Ou-Yang, ZC , Chinese Acad Sci, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
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GB/T 7714
Ou-Yang, ZC,Zhou, H,Zhang, Y,et al. The elastic theory of a single DNA molecule[J]. MODERN PHYSICS LETTERS B,2003,17(1):1-10.
APA Ou-Yang, ZC,Zhou, H,Zhang, Y,&Ou-Yang, ZC , Chinese Acad Sci, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2003).The elastic theory of a single DNA molecule.MODERN PHYSICS LETTERS B,17(1),1-10.
MLA Ou-Yang, ZC,et al."The elastic theory of a single DNA molecule".MODERN PHYSICS LETTERS B 17.1(2003):1-10.
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