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Limitations of compositional approach to identifying horizontally transferred genes
Wang, B; Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
2001
发表期刊JOURNAL OF MOLECULAR EVOLUTION
ISSN0022-2844
卷号53期号:3页码:244-250
摘要Genes with atypical G+C content and pattern of codon usage in a certain genome are possibly of exotic origin, and this idea has been applied to identify horizontal events. In this way, it was postulated that a total of 755 genes in the E. coli genome are relics of horizontal events after the divergence of E. coli from the Salmonella lineage 100 million years ago (Lawrence and Ochman. 1998). In this paper we propose a new way to study sequence composition more thoroughly. We found that although the 755 genes differ in composition from other genes in the E. coli genome. the difference is minor. If we accepted that these genes are horizontally transferred. then (1) it would be more likely that they were transferred from genomes evolutionarily closely related to E. coli: but (2) the dating method used by Lawrence and Ochman (1997, 1998) largely underestimated the average age of introduced sequences in the E. coli genome, in particular, most of the 755 genes should be introduced into E. coli before, instead of after, the divergence of E. coli from the Salmonella lineage. Our study reveals that atypical G+C content and pattern of codon usage are not reliable indicators of horizontal gene transfer events.
部门归属Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China; Inst Computat Math & Sci Engn Comp, State Key Lab Sci & Engn Comp, Beijing 100080, Peoples R China
关键词Escherichia-coli Genome Bacterial Hyperthermophiles Common Ancestry Archaeal Exchange Sequences Tree Life Divergence Evolution
学科领域Physics
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收录类别SCI
WOS记录号WOS:000170659000009
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被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/13673
专题理论物理所SCI论文
通讯作者Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
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Wang, B,Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.. Limitations of compositional approach to identifying horizontally transferred genes[J]. JOURNAL OF MOLECULAR EVOLUTION,2001,53(3):244-250.
APA Wang, B,&Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2001).Limitations of compositional approach to identifying horizontally transferred genes.JOURNAL OF MOLECULAR EVOLUTION,53(3),244-250.
MLA Wang, B,et al."Limitations of compositional approach to identifying horizontally transferred genes".JOURNAL OF MOLECULAR EVOLUTION 53.3(2001):244-250.
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