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Li, M; Ou-Yang, ZC; Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.
Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics
Source PublicationJOURNAL OF PHYSICS-CONDENSED MATTER
KeywordDomains Gene
AbstractEukaryotic chromatin undergoes a few steps of compaction to form a chromosome. Among the several levels of chromatin assembly, successive chromatin loops (5-100 kb) demarcated by the nuclear matrix are of primary importance since they behave as topologically independent domains for coordinate regulation of harboured genes. The bases of the loops are called SMARs (scaffold/matrix attachment regions). On one hand, this chromosome structure imposes stress on the DNA molecule since the double-stranded DNA is actually unwound and bent by histones and other proteins. On the other hand, the stressed DNA itself affects chromatin assembly inversely, e.g., the unwinding stress may promote SMAR binding to the matrix. The interplay between chromosome structure and unwinding stress contributes significantly to eukaryotic gene regulation. In this paper, we investigate two issues: how torsional stress may promote SMAR anchorage to the matrix; and how the formation of chromatin loops may affect basic biochemical processes. We employ the Benham model for these purposes. Our analysis gives theoretical evidence that at least some SMARs are unwound under torsional stress and at the same time could serve as topological barriers for retaining the torsional stress on the chromatin loop which may be necessary for gene transcription.
2005
ISSN0953-8984
Volume17Issue:31Pages:S2853-S2860
Subject AreaPhysics
Indexed BySCI
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/13763
Collection理论物理所科研产出_SCI论文
Corresponding AuthorLi, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.
Recommended Citation
GB/T 7714
Li, M,Ou-Yang, ZC,Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.. Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics[J]. JOURNAL OF PHYSICS-CONDENSED MATTER,2005,17(31):S2853-S2860.
APA Li, M,Ou-Yang, ZC,&Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China..(2005).Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics.JOURNAL OF PHYSICS-CONDENSED MATTER,17(31),S2853-S2860.
MLA Li, M,et al."Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics".JOURNAL OF PHYSICS-CONDENSED MATTER 17.31(2005):S2853-S2860.
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