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题名: Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics
作者: Li, M ;  Ou-Yang, ZC
刊名: JOURNAL OF PHYSICS-CONDENSED MATTER
出版日期: 2005
卷号: 17, 期号:31, 页码:S2853-S2860
关键词: DOMAINS ;  GENE
学科分类: Physics
通讯作者: Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.
部门归属: Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: Eukaryotic chromatin undergoes a few steps of compaction to form a chromosome. Among the several levels of chromatin assembly, successive chromatin loops (5-100 kb) demarcated by the nuclear matrix are of primary importance since they behave as topologically independent domains for coordinate regulation of harboured genes. The bases of the loops are called SMARs (scaffold/matrix attachment regions). On one hand, this chromosome structure imposes stress on the DNA molecule since the double-stranded DNA is actually unwound and bent by histones and other proteins. On the other hand, the stressed DNA itself affects chromatin assembly inversely, e.g., the unwinding stress may promote SMAR binding to the matrix. The interplay between chromosome structure and unwinding stress contributes significantly to eukaryotic gene regulation. In this paper, we investigate two issues: how torsional stress may promote SMAR anchorage to the matrix; and how the formation of chromatin loops may affect basic biochemical processes. We employ the Benham model for these purposes. Our analysis gives theoretical evidence that at least some SMARs are unwound under torsional stress and at the same time could serve as topological barriers for retaining the torsional stress on the chromatin loop which may be necessary for gene transcription.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000231935000012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/13763
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Li, M,Ou-Yang, ZC. Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics[J]. JOURNAL OF PHYSICS-CONDENSED MATTER,2005,17(31):S2853-S2860.
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