ITP OpenIR  > 理论物理所科研产出  > SCI论文
Liu, F; Ou-Yang, ZC; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
Monte Carlo simulation for single RNA unfolding by force
Source PublicationBIOPHYSICAL JOURNAL
KeywordMechanical Force Secondary Structure Kinetic-model Dna-molecules Stranded-dna Algorithm Information Pseudoknots Prediction Separation
AbstractUsing polymer elastic theory and known RNA free energies, we construct a Monte Carlo algorithm to simulate the single RNA folding and unfolding by mechanical force on the secondary structure level. For the constant force ensemble, we simulate the force-extension curves of the P5ab, P5abcDeltaA, and P5abc molecules in equilibrium. For the constant extension ensemble, we focus on the mechanical behaviors of the RNA P5ab molecule, which include the unfolding force dependence on the pulling speed, the force-hysteresis phenomenon, and the coincidence of stretching-relaxing force-curves in thermal equilibrium. We particularly simulate the time traces of the end-to-end distance of the P5ab under the constant force in equilibrium, which also have been recorded in the recent experiment. The reaction rate constants for the folding and unfolding are calculated. Our results show that the agreement between the simulation and the experimental measurements is satisfactory.
2005
ISSN0006-3495
Volume88Issue:1Pages:76-84
Subject AreaPhysics
Indexed BySCI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/13908
Collection理论物理所科研产出_SCI论文
Corresponding AuthorLiu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
Recommended Citation
GB/T 7714
Liu, F,Ou-Yang, ZC,Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.. Monte Carlo simulation for single RNA unfolding by force[J]. BIOPHYSICAL JOURNAL,2005,88(1):76-84.
APA Liu, F,Ou-Yang, ZC,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2005).Monte Carlo simulation for single RNA unfolding by force.BIOPHYSICAL JOURNAL,88(1),76-84.
MLA Liu, F,et al."Monte Carlo simulation for single RNA unfolding by force".BIOPHYSICAL JOURNAL 88.1(2005):76-84.
Files in This Item:
File Name/Size DocType Version Access License
Monte Carlo Simulati(191KB) 开放获取LicenseApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, F]'s Articles
[Ou-Yang, ZC]'s Articles
[Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, F]'s Articles
[Ou-Yang, ZC]'s Articles
[Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, F]'s Articles
[Ou-Yang, ZC]'s Articles
[Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.