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Wong, GKS; Liu, B; Wang, J; Zhang, Y; Yang, X; Zhang, ZJ; Meng, QS; Zhou, J; Li, DW; Zhang, JJ; Ni, PX; Li, SG; Ran, LH; Li, H; Zhang, JG; Li, RQ; Li, ST; Zheng, HK; Lin, W; Li, GY; Wang, XL; Zhao, WM; Li, J; Ye, C; Dai, MT; Ruan, J; Zhou, Y; Li, YZ; He, XM; Zhang, YZ; Huang, XG; Tong, W; Chen, J; Ye, J; Chen, C; Wei, N; Li, GQ; Dong, L; Lan, FD; Sun, YQ; Zhang, ZP; Yang, Z; Yu, YP; Huang, YQ; He, DD; Xi, Y; Wei, D; Qi, QH; Li, WJ; Shi, JP; Wang, MH; Xie, F; Wang, JJ; Zhang, XW; Wang, P; Zhao, YQ; Li, N; Yang, N; Dong, W; Hu, SN; Zeng, CQ; Zheng, WM ; Hao, BL; Hillier, LW; Yang, SP; Warren, WC; Wilson, RK; Brandstrom, M; Ellegren, H; Crooijmans, RPMA; van der Poel, JJ; Bovenhuis, H; Groenen, MAM; Ovcharenko, I; Gordon, L; Stubbs, L; Lucas, S; Glavina, T; Aerts, A; Kaiser, P; Rothwell, L; Young, JR; Rogers, S; Walker, BA; van Hateren, A; Kaufman, J; Bumstead, N; Lamont, SJ; Zhou, HJ; Hocking, PM; Morrice, D; de Koning, DJ; Law, A; Bartley, N; Burt, DW; Hunt, H; Cheng, HH; Gunnarsson, U; Wahlberg, P; Andersson, L; Kindlund, E; Tammi, MT; Andersson, B; Webber, C; Ponting, CP; Overton, IM; Boardman, PE; Tang, HZ; Hubbard, SJ; Wilson, SA; Yu, J; Yang, HM; Wong, GKS , Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China.
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| A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms | |
| Source Publication | NATURE
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| Keyword | Quantitative Trait Loci Broiler Layer Cross Genome Diversity Sequence Mutation Markers Growth Snp |
| Abstract | We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle fowl. Subsequent experiments indicate that at least 90% of the variant sites are true SNPs, and at least 70% are common SNPs that segregate in many domestic breeds. Mean nucleotide diversity is about five SNPs per kilobase for almost every possible comparison between red jungle fowl and domestic lines, between two different domestic lines, and within domestic lines - in contrast to the notion that domestic animals are highly inbred relative to their wild ancestors. In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases. |
| 2004 | |
| ISSN | 0028-0836 |
| Volume | 432Issue:7018Pages:717-722 |
| Subject Area | Physics |
| Indexed By | SCI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.itp.ac.cn/handle/311006/13926 |
| Collection | SCI期刊论文 |
| Corresponding Author | Wong, GKS , Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China. |
| Recommended Citation GB/T 7714 | Wong, GKS,Liu, B,Wang, J,et al. A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms[J]. NATURE,2004,432(7018):717-722. |
| APA | Wong, GKS.,Liu, B.,Wang, J.,Zhang, Y.,Yang, X.,...&Wong, GKS , Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China..(2004).A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms.NATURE,432(7018),717-722. |
| MLA | Wong, GKS,et al."A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms".NATURE 432.7018(2004):717-722. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| A genetic variation （279KB） | 开放获取 | License | Application Full Text | |||
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