Wong, GKS , Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China.
部门归属:
Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China; Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou Genom Inst, Key Lab Genom Bioinformat Zhejiang Prov, Hangzhou 310008, Peoples R China; Univ Washington, Dept Med, UW Genome Ctr, Seattle, WA 98195 USA; Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China; Beijing N Computat Ctr, Beijing 100091, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China; China Agr Univ, Beijing 100094, Peoples R China; Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA; Uppsala Univ, Evolutionary Biol Ctr, Dept Evolutionay Biol, SE-75234 Uppsala, Sweden; Univ Wageningen & Res Ctr, Anim Breeding & Genet Grp, NL-6709 PG Wageningen, Netherlands; Lawrence Livermore Natl Lab, Genome Biol Div, Livermore, CA 94550 USA; US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA; Inst Anim Hlth, Compton RG20 7NN, Berks, England; Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA; Roslin Inst Edinburgh, Roslin EH25 9PS, Midlothian, Scotland; USDA ARS, Avian Dis & Oncol Lab, E Lansing, MI 48823 USA; Uppsala Univ, Dept Med Biochem & Microbiol, SE-75124 Uppsala, Sweden; Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75124 Uppsala, Sweden; Karolinska Inst, Ctr Genom & Bioinformat, SE-17177 Stockholm, Sweden; Natl Univ Singapore, Dept Biol Sci, Singapore 117548, Singapore; Natl Univ Singapore, Dept Biochem, Singapore 117548, Singapore; Univ Oxford, Dept Human Anat & Genet, MRC, Funct Gent Unit, Oxford OX1 3QX, England; Univ Manchester, Inst Sci & Technol, Dept Biomol Sci, Manchester M60 1QD, Lancs, England; Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England
英文摘要:
We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle fowl. Subsequent experiments indicate that at least 90% of the variant sites are true SNPs, and at least 70% are common SNPs that segregate in many domestic breeds. Mean nucleotide diversity is about five SNPs per kilobase for almost every possible comparison between red jungle fowl and domestic lines, between two different domestic lines, and within domestic lines - in contrast to the notion that domestic animals are highly inbred relative to their wild ancestors. In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases.
Wong, GKS,Liu, B,Wang, J,et al. A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms[J]. NATURE,2004,432(7018):717-722.
