A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms

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	Wong, GKS; Liu, B; Wang, J; Zhang, Y; Yang, X; Zhang, ZJ; Meng, QS; Zhou, J; Li, DW; Zhang, JJ; Ni, PX; Li, SG; Ran, LH; Li, H; Zhang, JG; Li, RQ; Li, ST; Zheng, HK; Lin, W; Li, GY; Wang, XL; Zhao, WM; Li, J; Ye, C; Dai, MT; Ruan, J; Zhou, Y; Li, YZ; He, XM; Zhang, YZ; Huang, XG; Tong, W; Chen, J; Ye, J; Chen, C; Wei, N; Li, GQ; Dong, L; Lan, FD; Sun, YQ; Zhang, ZP; Yang, Z; Yu, YP; Huang, YQ; He, DD; Xi, Y; Wei, D; Qi, QH; Li, WJ; Shi, JP; Wang, MH; Xie, F; Wang, JJ; Zhang, XW; Wang, P; Zhao, YQ; Li, N; Yang, N; Dong, W; Hu, SN; Zeng, CQ; Zheng, WM; Hao, BL; Hillier, LW; Yang, SP; Warren, WC; Wilson, RK; Brandstrom, M; Ellegren, H; Crooijmans, RPMA; van der Poel, JJ; Bovenhuis, H; Groenen, MAM; Ovcharenko, I; Gordon, L; Stubbs, L; Lucas, S; Glavina, T; Aerts, A; Kaiser, P; Rothwell, L; Young, JR; Rogers, S; Walker, BA; van Hateren, A; Kaufman, J; Bumstead, N; Lamont, SJ; Zhou, HJ; Hocking, PM; Morrice, D; de Koning, DJ; Law, A; Bartley, N; Burt, DW; Hunt, H; Cheng, HH; Gunnarsson, U; Wahlberg, P; Andersson, L; Kindlund, E; Tammi, MT; Andersson, B; Webber, C; Ponting, CP; Overton, IM; Boardman, PE; Tang, HZ; Hubbard, SJ; Wilson, SA; Yu, J; Yang, HM; Wong, GKS , Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China.
	A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
发表期刊	NATURE
关键词	Quantitative Trait Loci Broiler Layer Cross Genome Diversity Sequence Mutation Markers Growth Snp
摘要	We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle fowl. Subsequent experiments indicate that at least 90% of the variant sites are true SNPs, and at least 70% are common SNPs that segregate in many domestic breeds. Mean nucleotide diversity is about five SNPs per kilobase for almost every possible comparison between red jungle fowl and domestic lines, between two different domestic lines, and within domestic lines - in contrast to the notion that domestic animals are highly inbred relative to their wild ancestors. In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases.
	2004
ISSN	0028-0836
卷号	432 期号:7018 页码:717-722
学科领域	Physics
收录类别	SCI
引用统计	被引频次：318[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.itp.ac.cn/handle/311006/13926
专题	理论物理所科研产出_SCI论文
通讯作者	Wong, GKS , Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China.
推荐引用方式 GB/T 7714	Wong, GKS,Liu, B,Wang, J,et al. A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms[J]. NATURE,2004,432(7018):717-722.
APA	Wong, GKS.,Liu, B.,Wang, J.,Zhang, Y.,Yang, X.,...&Wong, GKS , Chinese Acad Sci, Beijing Inst Genom, Beijing Proteom Inst, Beijing 101300, Peoples R China..(2004).A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms.NATURE,432(7018),717-722.
MLA	Wong, GKS,et al."A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms".NATURE 432.7018(2004):717-722.

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