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Unfolding single RNA molecules by mechanical force: A stochastic kinetic method
Liu, F; Ou-Yang, ZC; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
2004
发表期刊PHYSICAL REVIEW E
ISSN1539-3755
卷号70期号:4页码:-
摘要Using simple polymer elastic theory and known RNA free energies, we study the single RNA folding and unfolding on the secondary structure level under mechanical constant force by stochastic kinetic simulation. As a primary application, this method is used to simulate the experiment performed by Liphardt et al. [Science 292, 733 (2001)]. The extension-force curves in equilibrium and kinetic reaction rate constants for folding and unfolding are calculated. Our results show that the agreement between simulation and experimental measurements is satisfactory.
部门归属Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Titin Immunoglobulin Domains Secondary Structure Stranded-dna Protein Elasticity Simulation Algorithm Dynamics Models
学科领域Physics
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收录类别SCI
WOS记录号WOS:000225689500006
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/13995
专题理论物理所1978-2010年知识产出
通讯作者Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
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GB/T 7714
Liu, F,Ou-Yang, ZC,Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.. Unfolding single RNA molecules by mechanical force: A stochastic kinetic method[J]. PHYSICAL REVIEW E,2004,70(4):-.
APA Liu, F,Ou-Yang, ZC,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2004).Unfolding single RNA molecules by mechanical force: A stochastic kinetic method.PHYSICAL REVIEW E,70(4),-.
MLA Liu, F,et al."Unfolding single RNA molecules by mechanical force: A stochastic kinetic method".PHYSICAL REVIEW E 70.4(2004):-.
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