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Liu, F; Ou-Yang, ZC; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
Unfolding single RNA molecules by mechanical force: A stochastic kinetic method
Source PublicationPHYSICAL REVIEW E
KeywordTitin Immunoglobulin Domains Secondary Structure Stranded-dna Protein Elasticity Simulation Algorithm Dynamics Models
AbstractUsing simple polymer elastic theory and known RNA free energies, we study the single RNA folding and unfolding on the secondary structure level under mechanical constant force by stochastic kinetic simulation. As a primary application, this method is used to simulate the experiment performed by Liphardt et al. [Science 292, 733 (2001)]. The extension-force curves in equilibrium and kinetic reaction rate constants for folding and unfolding are calculated. Our results show that the agreement between simulation and experimental measurements is satisfactory.
2004
ISSN1539-3755
Volume70Issue:4Pages:-
Subject AreaPhysics
Indexed BySCI
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/13995
CollectionSCI期刊论文
Corresponding AuthorLiu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
Recommended Citation
GB/T 7714
Liu, F,Ou-Yang, ZC,Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.. Unfolding single RNA molecules by mechanical force: A stochastic kinetic method[J]. PHYSICAL REVIEW E,2004,70(4):-.
APA Liu, F,Ou-Yang, ZC,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2004).Unfolding single RNA molecules by mechanical force: A stochastic kinetic method.PHYSICAL REVIEW E,70(4),-.
MLA Liu, F,et al."Unfolding single RNA molecules by mechanical force: A stochastic kinetic method".PHYSICAL REVIEW E 70.4(2004):-.
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