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题名: Whole proteome prokaryote phylogeny without sequence alignment: A K-string composition approach
作者: Qi, J ;  Wang, B ;  Hao, BI
刊名: JOURNAL OF MOLECULAR EVOLUTION
出版日期: 2004
卷号: 58, 期号:1, 页码:1-11
关键词: UNIVERSAL TREE ;  LIFE ;  ARCHAEAL
学科分类: Physics
通讯作者: Qi, J , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
部门归属: Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China; Fudan Univ, T Life Res Ctr, Shanghai 200433, Peoples R China
英文摘要: A systematic way of inferring evolutionary relatedness of microbial organisms from the oligopeptide content, i.e., frequency of amino acid K-strings in their complete proteomes, is proposed. The new method circumvents the ambiguity of choosing the genes for phylogenetic reconstruction and avoids the necessity of aligning sequences of essentially different length and gene content. The only "parameter" in the method is the length K of the oligopeptides, which serves to tune the "resolution power" of the method. The topology of the trees converges with K increasing. Applied to a total of 109 organisms, including 16 Archaea, 87 Bacteria, and 6 Eukarya, it yields an unrooted tree that agrees with the biologists' "tree of life" based on SSU rRNA comparison in a majority of basic branchings, and especially, in all lower taxa.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000188112200001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/14146
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Qi, J,Wang, B,Hao, BI. Whole proteome prokaryote phylogeny without sequence alignment: A K-string composition approach[J]. JOURNAL OF MOLECULAR EVOLUTION,2004,58(1):1-11.
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