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Hao, Y; Xu, LF; Shi, HL; Shi, HL (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
Theoretical Analysis of Catalytic-sRNA-Mediated Gene Silencing
发表期刊JOURNAL OF MOLECULAR BIOLOGY
语种英语
关键词Transcriptional Regulation Escherichia-coli Regulatory Rnas Bacteria Expression Noise Consequences Numbers Stress System
摘要Small regulatory RNA (sRNA) that acts by an antisense mechanism is critical for gene regulation at the posttranscriptional level. Recently, an Hfq-dependent sRNA named MicM, which is related to the regulation of outer membrane protein, was verified as a novel antisense sRNA due to its catalytic mode of regulation. Here we propose a simple kinetic model for the enzyme-like regulation mode of sRNA and study in detail the noise properties of the target gene under various recycling rates of the regulator. We predict that the recycling rate of sRNA and other relative parameters have significant influence on the noise strength of target expression. In comparison with the stoichiometric regulatory mode, a lesser fluctuation of target expression was observed near the threshold at which the transcription rates of both sRNA and target mRNA equal each other. We also found that the new mode is better in terms of rapid response to external signals. However, it needs more time to achieve target recovery if the stimulating signal disappears. Additionally, the obtained time evolution results of the MicM-ybfM interaction system based on our model are consistent with previous experimental results, serving as experimental evidence to back up our theoretical analysis. (C) 2010 Elsevier Ltd. All rights reserved.
2011
ISSN0022-2836
卷号406期号:1页码:195-204
学科领域Physics
收录类别SCI
项目资助者National Basic Research Program of China [2007CB814800] ; National Basic Research Program of China [2007CB814800] ; National Basic Research Program of China [2007CB814800] ; National Basic Research Program of China [2007CB814800]
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文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/14411
专题理论物理所科研产出_SCI论文
通讯作者Shi, HL (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
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Hao, Y,Xu, LF,Shi, HL,et al. Theoretical Analysis of Catalytic-sRNA-Mediated Gene Silencing[J]. JOURNAL OF MOLECULAR BIOLOGY,2011,406(1):195-204.
APA Hao, Y,Xu, LF,Shi, HL,&Shi, HL .(2011).Theoretical Analysis of Catalytic-sRNA-Mediated Gene Silencing.JOURNAL OF MOLECULAR BIOLOGY,406(1),195-204.
MLA Hao, Y,et al."Theoretical Analysis of Catalytic-sRNA-Mediated Gene Silencing".JOURNAL OF MOLECULAR BIOLOGY 406.1(2011):195-204.
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