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题名: Understanding gene circuits at cell-fate branch points for rational cell reprogramming
作者: Zhou, JX ;  Huang, S
刊名: TRENDS IN GENETICS
出版日期: 2011
卷号: 27, 期号:2, 页码:55-62
关键词: HEMATOPOIETIC STEM-CELLS ;  TRANSCRIPTION FACTORS ;  POTENTIAL LANDSCAPE ;  PROGENITOR CELLS ;  PU.1 ;  GATA-1 ;  DIFFERENTIATION ;  SPECIFICATION ;  EXPRESSION ;  NOISE
学科分类: Physics
通讯作者: Huang, S (reprint author), Univ Calgary, Inst Biocomplex & Informat, Biol Sci Bldg,2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
部门归属: [Zhou, Joseph X.; Huang, Sui] Univ Calgary, Inst Biocomplex & Informat, Calgary, AB T2N 1N4, Canada; [Zhou, Joseph X.; Huang, Sui] CAS, Kavli Inst Theoret Phys China, Beijing 100190, Peoples R China
英文摘要: Cell-type reprogramming, the artificial induction of a switch of cell lineage and developmental stage, holds great promise for regenerative medicine. However, how does the metazoan body itself 'program' the various cell lineages in the first place? Knowledge of how multipotent cells make cell-fate decisions and commit to a particular lineage is crucial for a rational reprogramming strategy and to avoid trial-and-error approaches in choosing the appropriate set of transcription factors to use. In the past few years, a general principle has emerged in which small gene circuits of cross-inhibition and self-activation govern the decision at branch points of cell development. A formal theoretical treatment of such circuits that deal with their dynamics on the 'epigenetic landscape' could offer some guidance to find the optimal way of cell reprogramming.
资助者: Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; iCore (Alberta Innovates)
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000287349300003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/14425
Appears in Collections:理论物理所2011年知识产出_期刊论文

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Recommended Citation:
Zhou, JX,Huang, S. Understanding gene circuits at cell-fate branch points for rational cell reprogramming[J]. TRENDS IN GENETICS,2011,27(2):55-62.
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