ITP OpenIR  > SCI期刊论文
Zhou, JX; Huang, S; Huang, S (reprint author), Univ Calgary, Inst Biocomplex & Informat, Biol Sci Bldg,2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
Understanding gene circuits at cell-fate branch points for rational cell reprogramming
Source PublicationTRENDS IN GENETICS
Language英语
KeywordHematopoietic Stem-cells Transcription Factors Potential Landscape Progenitor Cells Pu.1 Gata-1 Differentiation Specification Expression Noise
AbstractCell-type reprogramming, the artificial induction of a switch of cell lineage and developmental stage, holds great promise for regenerative medicine. However, how does the metazoan body itself 'program' the various cell lineages in the first place? Knowledge of how multipotent cells make cell-fate decisions and commit to a particular lineage is crucial for a rational reprogramming strategy and to avoid trial-and-error approaches in choosing the appropriate set of transcription factors to use. In the past few years, a general principle has emerged in which small gene circuits of cross-inhibition and self-activation govern the decision at branch points of cell development. A formal theoretical treatment of such circuits that deal with their dynamics on the 'epigenetic landscape' could offer some guidance to find the optimal way of cell reprogramming.
2011
ISSN0168-9525
Volume27Issue:2Pages:55-62
Subject AreaPhysics
Indexed BySCI
Funding OrganizationCanadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; iCore (Alberta Innovates) ; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; iCore (Alberta Innovates) ; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; iCore (Alberta Innovates) ; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; iCore (Alberta Innovates)
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/14425
CollectionSCI期刊论文
Corresponding AuthorHuang, S (reprint author), Univ Calgary, Inst Biocomplex & Informat, Biol Sci Bldg,2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
Recommended Citation
GB/T 7714
Zhou, JX,Huang, S,Huang, S . Understanding gene circuits at cell-fate branch points for rational cell reprogramming[J]. TRENDS IN GENETICS,2011,27(2):55-62.
APA Zhou, JX,Huang, S,&Huang, S .(2011).Understanding gene circuits at cell-fate branch points for rational cell reprogramming.TRENDS IN GENETICS,27(2),55-62.
MLA Zhou, JX,et al."Understanding gene circuits at cell-fate branch points for rational cell reprogramming".TRENDS IN GENETICS 27.2(2011):55-62.
Files in This Item:
File Name/Size DocType Version Access License
Understanding gene c(634KB) 开放获取LicenseApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, JX]'s Articles
[Huang, S]'s Articles
[Huang, S (reprint author), Univ Calgary, Inst Biocomplex & Informat, Biol Sci Bldg,2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, JX]'s Articles
[Huang, S]'s Articles
[Huang, S (reprint author), Univ Calgary, Inst Biocomplex & Informat, Biol Sci Bldg,2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, JX]'s Articles
[Huang, S]'s Articles
[Huang, S (reprint author), Univ Calgary, Inst Biocomplex & Informat, Biol Sci Bldg,2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.