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Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli
Zhang, Q; Shi, HL; Shi, HL (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
2012
发表期刊JOURNAL OF THEORETICAL BIOLOGY
ISSN0022-5193
卷号314期号:-页码:164-172
摘要The initiation of chromosomal replication is strictly controlled during the cell cycle. Its frequency needs to be well-matched to the proliferation rate. In many bacteria, DnaA is the critical mediator in the regulation of replication initiation. In this work, the initiation probability is deduced based on the distribution of DnaA boxes at oriC in Escherichia coli. Taking into account more details, we develop a dynamic model to describe the oscillation of DnaA accompanied with the cell cycles. Our simulations show that the regulation of DnaA couples chromosomal replication to cell growth. We also discuss effects of other factors on DnaA oscillation. We propose that RNA polymerase is one of the candidates for harmonizing chromosomal replication and cell growth by adjusting dnaA transcriptional activity. (C) 2012 Elsevier Ltd. All rights reserved.
部门归属[Zhang, Qing; Shi, Hualin] Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China
关键词Sequential Binding Auto-regulation Division Cycle Gene Promoter Adp-dnaa Origin Sites Model K-12 Seqa
学科领域Physics
资助者National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320]
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收录类别SCI
语种英语
资助者National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320] ; National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320]
WOS记录号WOS:000310652900017
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/14958
专题理论物理所SCI论文
通讯作者Shi, HL (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
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Zhang, Q,Shi, HL,Shi, HL . Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli[J]. JOURNAL OF THEORETICAL BIOLOGY,2012,314(-):164-172.
APA Zhang, Q,Shi, HL,&Shi, HL .(2012).Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli.JOURNAL OF THEORETICAL BIOLOGY,314(-),164-172.
MLA Zhang, Q,et al."Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli".JOURNAL OF THEORETICAL BIOLOGY 314.-(2012):164-172.
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