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题名: Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli
作者: Zhang, Q ;  Shi, HL
刊名: JOURNAL OF THEORETICAL BIOLOGY
出版日期: 2012
卷号: 314, 期号:-, 页码:164-172
关键词: SEQUENTIAL BINDING ;  AUTO-REGULATION ;  DIVISION CYCLE ;  GENE PROMOTER ;  ADP-DNAA ;  ORIGIN ;  SITES ;  MODEL ;  K-12 ;  SEQA
学科分类: Physics
通讯作者: Shi, HL (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
部门归属: [Zhang, Qing; Shi, Hualin] Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China
英文摘要: The initiation of chromosomal replication is strictly controlled during the cell cycle. Its frequency needs to be well-matched to the proliferation rate. In many bacteria, DnaA is the critical mediator in the regulation of replication initiation. In this work, the initiation probability is deduced based on the distribution of DnaA boxes at oriC in Escherichia coli. Taking into account more details, we develop a dynamic model to describe the oscillation of DnaA accompanied with the cell cycles. Our simulations show that the regulation of DnaA couples chromosomal replication to cell growth. We also discuss effects of other factors on DnaA oscillation. We propose that RNA polymerase is one of the candidates for harmonizing chromosomal replication and cell growth by adjusting dnaA transcriptional activity. (C) 2012 Elsevier Ltd. All rights reserved.
资助者: National Basic Research Program of China [2007CB814800]; National Natural Science Foundation of China [11121403, 11274320]
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000310652900017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/14958
Appears in Collections:理论物理所2012年知识产出_期刊论文

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Recommended Citation:
Zhang, Q,Shi, HL. Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli[J]. JOURNAL OF THEORETICAL BIOLOGY,2012,314(-):164-172.
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