ITP OpenIR  > 理论物理所2012年知识产出
The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model
Shu, YG; Zhang, XH; Ou-Yang, ZC; Li, M; Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
2012
发表期刊JOURNAL OF PHYSICS-CONDENSED MATTER
ISSN0953-8984
卷号24期号:3页码:35105
摘要The neck linker is widely believed to play a critical role in the hand-over-hand walking of conventional kinesin 1. Experiments have shown that change of the neck linker length will significantly change the stepping velocity of the motor. In this paper, we studied this length effect based on a highly simplified chemically powered ratchet model. In this model, we assume that the chemical steps (ATP hydrolysis, ADP and P(i) release, ATP binding, neck linker docking) are fast enough under conditions far from equilibrium and the mechanical steps (detachment, diffusional search and re-attachment of the free head) are rate-limiting in kinesin walking. According to this model, and regarding the neck linker as a worm-like-chain polypeptide, we can calculate the steady state stepping velocity of the motor for different neck linker lengths. Our results show, under the actual values of binding energy between kinesin head and microtubule (similar to 15k(BT)) and the persistence length of neck linker (similar to 0.5 nm), that there is an optimal neck linker length (similar to 14-16 a.a.) corresponding to the maximal velocity, which implies that the length of the wild-type neck linker (similar to 15 a.a.) might be optimally designed for kinesin 1 to approach the largest stepping velocity.
部门归属[Shu, Yao-Gen; Zhang, Xiao-Hu; Ou-Yang, Zhong-Can] Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China; [Zhang, Xiao-Hu; Li, Ming] Chinese Acad Sci, Grad Univ, Coll Phys Sci, Beijing 100190, Peoples R China
关键词Hand-over-hand Microtubule-based Motility Atp Hydrolysis Motor Domains Force-field Internal Strain Swing Model Processivity Mechanism Steps
学科领域Physics
资助者National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903]
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收录类别SCI
语种英语
资助者National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903]
WOS记录号WOS:000298641600005
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/15178
专题理论物理所2012年知识产出
通讯作者Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
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Shu, YG,Zhang, XH,Ou-Yang, ZC,et al. The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model[J]. JOURNAL OF PHYSICS-CONDENSED MATTER,2012,24(3):35105.
APA Shu, YG,Zhang, XH,Ou-Yang, ZC,Li, M,&Shu, YG .(2012).The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model.JOURNAL OF PHYSICS-CONDENSED MATTER,24(3),35105.
MLA Shu, YG,et al."The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model".JOURNAL OF PHYSICS-CONDENSED MATTER 24.3(2012):35105.
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