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Shu, YG; Zhang, XH; Ou-Yang, ZC; Li, M; Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model
Source PublicationJOURNAL OF PHYSICS-CONDENSED MATTER
Language英语
KeywordHand-over-hand Microtubule-based Motility Atp Hydrolysis Motor Domains Force-field Internal Strain Swing Model Processivity Mechanism Steps
AbstractThe neck linker is widely believed to play a critical role in the hand-over-hand walking of conventional kinesin 1. Experiments have shown that change of the neck linker length will significantly change the stepping velocity of the motor. In this paper, we studied this length effect based on a highly simplified chemically powered ratchet model. In this model, we assume that the chemical steps (ATP hydrolysis, ADP and P(i) release, ATP binding, neck linker docking) are fast enough under conditions far from equilibrium and the mechanical steps (detachment, diffusional search and re-attachment of the free head) are rate-limiting in kinesin walking. According to this model, and regarding the neck linker as a worm-like-chain polypeptide, we can calculate the steady state stepping velocity of the motor for different neck linker lengths. Our results show, under the actual values of binding energy between kinesin head and microtubule (similar to 15k(BT)) and the persistence length of neck linker (similar to 0.5 nm), that there is an optimal neck linker length (similar to 14-16 a.a.) corresponding to the maximal velocity, which implies that the length of the wild-type neck linker (similar to 15 a.a.) might be optimally designed for kinesin 1 to approach the largest stepping velocity.
2012
ISSN0953-8984
Volume24Issue:3Pages:35105
Subject AreaPhysics
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903] ; National Natural Science Foundation of China [91027045, 11075015]; National Basic Research Program of China (973 Program) [2007CB935903]
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/15178
Collection理论物理所科研产出_SCI论文
Corresponding AuthorShu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Shu, YG,Zhang, XH,Ou-Yang, ZC,et al. The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model[J]. JOURNAL OF PHYSICS-CONDENSED MATTER,2012,24(3):35105.
APA Shu, YG,Zhang, XH,Ou-Yang, ZC,Li, M,&Shu, YG .(2012).The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model.JOURNAL OF PHYSICS-CONDENSED MATTER,24(3),35105.
MLA Shu, YG,et al."The neck linker of kinesin 1 seems optimally designed to approach the largest stepping velocity: a simulation study of an ideal model".JOURNAL OF PHYSICS-CONDENSED MATTER 24.3(2012):35105.
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