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Wang, ZQ; Shu, YG; Li, M; Li, M (reprint author), Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China.
A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube
发表期刊COMMUNICATIONS IN THEORETICAL PHYSICS
语种英语
关键词Molecular Motors Living Cells Dynamics Transport
摘要Membrane tubes are important functional elements for living cells. Experiments have found that membrane tubes can be extracted from giant lipid vesicles by groups of kinesin. How these motors cooperate in extracting the membrane tube is a very important issue but still unclear so far. In this paper, we propose a cooperation mechanism called two-track-dumbbell model, in which kinesin is regarded as a dumbbell with an end (tail domain) tethered on the fluid-like membrane and the other end (head domain) stepping on the microtubule. Taking account of the elasticity of kinesin molecule and the excluded volume effect of both the head domain and the tail domain of kinesin, which are not considered in previous models, we simulate the growth process of the membrane tube pulled by kinesin motors. Our results indicate that in the case of strong or moderate exclusion of motor tails, the average number of motors pulling the tube can be as high as 9 and thus motors moving along a single microtubule protofilament can generate enough force to extract membrane tubes from vesicles. This result is different from previous studies and may be tested by future experiments.
2013
ISSN0253-6102
卷号60期号:6页码:753-760
学科领域Physics
收录类别SCI
项目资助者National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218]
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文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/15217
专题理论物理所科研产出_SCI论文
通讯作者Li, M (reprint author), Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China.
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Wang, ZQ,Shu, YG,Li, M,et al. A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2013,60(6):753-760.
APA Wang, ZQ,Shu, YG,Li, M,&Li, M .(2013).A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube.COMMUNICATIONS IN THEORETICAL PHYSICS,60(6),753-760.
MLA Wang, ZQ,et al."A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube".COMMUNICATIONS IN THEORETICAL PHYSICS 60.6(2013):753-760.
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