ITP OpenIR  > 理论物理所2013年知识产出
A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube
Wang, ZQ; Shu, YG; Li, M; Li, M (reprint author), Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China.
2013
发表期刊COMMUNICATIONS IN THEORETICAL PHYSICS
ISSN0253-6102
卷号60期号:6页码:753-760
摘要Membrane tubes are important functional elements for living cells. Experiments have found that membrane tubes can be extracted from giant lipid vesicles by groups of kinesin. How these motors cooperate in extracting the membrane tube is a very important issue but still unclear so far. In this paper, we propose a cooperation mechanism called two-track-dumbbell model, in which kinesin is regarded as a dumbbell with an end (tail domain) tethered on the fluid-like membrane and the other end (head domain) stepping on the microtubule. Taking account of the elasticity of kinesin molecule and the excluded volume effect of both the head domain and the tail domain of kinesin, which are not considered in previous models, we simulate the growth process of the membrane tube pulled by kinesin motors. Our results indicate that in the case of strong or moderate exclusion of motor tails, the average number of motors pulling the tube can be as high as 9 and thus motors moving along a single microtubule protofilament can generate enough force to extract membrane tubes from vesicles. This result is different from previous studies and may be tested by future experiments.
部门归属[Wang Zi-Qing] Northwest A&F Univ, Coll Sci, Yangling 712100, Peoples R China; [Wang Zi-Qing] Northwest A&F Univ, Inst Biophys, Yangling 712100, Peoples R China; [Shu Yao-Gen] Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China; [Li Ming] Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China
关键词Molecular Motors Living Cells Dynamics Transport
学科领域Physics
资助者National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218]
收录类别SCI
语种英语
资助者National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218]
WOS记录号WOS:000330882300020
引用统计
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/15217
专题理论物理所2013年知识产出
通讯作者Li, M (reprint author), Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China.
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GB/T 7714
Wang, ZQ,Shu, YG,Li, M,et al. A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2013,60(6):753-760.
APA Wang, ZQ,Shu, YG,Li, M,&Li, M .(2013).A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube.COMMUNICATIONS IN THEORETICAL PHYSICS,60(6),753-760.
MLA Wang, ZQ,et al."A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube".COMMUNICATIONS IN THEORETICAL PHYSICS 60.6(2013):753-760.
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