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Wang, ZQ; Shu, YG; Li, M; Li, M (reprint author), Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China.
A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube
Source PublicationCOMMUNICATIONS IN THEORETICAL PHYSICS
Language英语
KeywordMolecular Motors Living Cells Dynamics Transport
AbstractMembrane tubes are important functional elements for living cells. Experiments have found that membrane tubes can be extracted from giant lipid vesicles by groups of kinesin. How these motors cooperate in extracting the membrane tube is a very important issue but still unclear so far. In this paper, we propose a cooperation mechanism called two-track-dumbbell model, in which kinesin is regarded as a dumbbell with an end (tail domain) tethered on the fluid-like membrane and the other end (head domain) stepping on the microtubule. Taking account of the elasticity of kinesin molecule and the excluded volume effect of both the head domain and the tail domain of kinesin, which are not considered in previous models, we simulate the growth process of the membrane tube pulled by kinesin motors. Our results indicate that in the case of strong or moderate exclusion of motor tails, the average number of motors pulling the tube can be as high as 9 and thus motors moving along a single microtubule protofilament can generate enough force to extract membrane tubes from vesicles. This result is different from previous studies and may be tested by future experiments.
2013
ISSN0253-6102
Volume60Issue:6Pages:753-760
Subject AreaPhysics
Indexed BySCI
Funding OrganizationNational Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218] ; National Basic Research Program of China (973 Program) [2013CB932800]; National Natural Science Foundation of China [11205123, 11075015, 11105218]
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Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/15217
Collection理论物理所科研产出_SCI论文
Corresponding AuthorLi, M (reprint author), Univ Chinese Acad Sci, Coll Phys Sci, Beijing 100049, Peoples R China.
Recommended Citation
GB/T 7714
Wang, ZQ,Shu, YG,Li, M,et al. A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2013,60(6):753-760.
APA Wang, ZQ,Shu, YG,Li, M,&Li, M .(2013).A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube.COMMUNICATIONS IN THEORETICAL PHYSICS,60(6),753-760.
MLA Wang, ZQ,et al."A New Cooperation Mechanism of Kinesin Motors when Extracting Membrane Tube".COMMUNICATIONS IN THEORETICAL PHYSICS 60.6(2013):753-760.
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