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题名: Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule
作者: Zhang, YX
刊名: JOURNAL OF STATISTICAL PHYSICS
出版日期: 2013
卷号: 152, 期号:6, 页码:1207-1221
关键词: HAND-OVER-HAND ;  CYTOPLASMIC DYNEIN ;  MYOSIN-V ;  EXCLUSION PROCESS ;  MOTOR ;  MOTILITY ;  DISEASE ;  WALKS
学科分类: Physics
通讯作者: Zhang, YX (reprint author), Fudan Univ, Shanghai Key Lab Contemporary Appl Math, Ctr Computat Syst Biol, Sch Math Sci, Shanghai 200433, Peoples R China.
部门归属: [Zhang, Yunxin] Fudan Univ, Shanghai Key Lab Contemporary Appl Math, Ctr Computat Syst Biol, Sch Math Sci, Shanghai 200433, Peoples R China; [Zhang, Yunxin] Chinese Acad Sci, Kavli Inst Theoret Phys China, Beijing 10090, Peoples R China
英文摘要: Recently, a three-state model is presented to describe the intracellular traffic of unconventional (single-headed) kinesin KIF1A (Phys. Rev. Lett. 95:118101, 2005), in which each motor can bind strongly or weakly to its microtubule track, and each binding site of the track might be empty or occupied by one motor. As the usual two-state model, i.e. the totally asymmetric simple exclusion process (TASEP) with motor detachment and attachment, in steady state of the system, this three-state model also exhibits shock (or domain wall separating the high-density and low density phases) and boundary layers. In this study, using mean-field analysis, the conditions of existence of shock and boundary layers are obtained theoretically. Combined with numerical calculations, the properties of shock are also studied. This study will be helpful to understand the biophysical properties of the collective transport of kinesin KIF1A.
资助者: Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804]
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000323203800009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/15290
Appears in Collections:理论物理所2013年知识产出 _期刊论文

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Recommended Citation:
Zhang, YX. Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule[J]. JOURNAL OF STATISTICAL PHYSICS,2013,152(6):1207-1221.
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