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Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule
Zhang, YX; Zhang, YX (reprint author), Fudan Univ, Shanghai Key Lab Contemporary Appl Math, Ctr Computat Syst Biol, Sch Math Sci, Shanghai 200433, Peoples R China.
2013
发表期刊JOURNAL OF STATISTICAL PHYSICS
ISSN0022-4715
卷号152期号:6页码:1207-1221
摘要Recently, a three-state model is presented to describe the intracellular traffic of unconventional (single-headed) kinesin KIF1A (Phys. Rev. Lett. 95:118101, 2005), in which each motor can bind strongly or weakly to its microtubule track, and each binding site of the track might be empty or occupied by one motor. As the usual two-state model, i.e. the totally asymmetric simple exclusion process (TASEP) with motor detachment and attachment, in steady state of the system, this three-state model also exhibits shock (or domain wall separating the high-density and low density phases) and boundary layers. In this study, using mean-field analysis, the conditions of existence of shock and boundary layers are obtained theoretically. Combined with numerical calculations, the properties of shock are also studied. This study will be helpful to understand the biophysical properties of the collective transport of kinesin KIF1A.
部门归属[Zhang, Yunxin] Fudan Univ, Shanghai Key Lab Contemporary Appl Math, Ctr Computat Syst Biol, Sch Math Sci, Shanghai 200433, Peoples R China; [Zhang, Yunxin] Chinese Acad Sci, Kavli Inst Theoret Phys China, Beijing 10090, Peoples R China
关键词Hand-over-hand Cytoplasmic Dynein Myosin-v Exclusion Process Motor Motility Disease Walks
学科领域Physics
资助者Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804]
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收录类别SCI
语种英语
资助者Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804] ; Natural Science Foundation of China [11271083]; Natural Science Foundation of Shanghai [11ZR1403700]; National Basic Research Program of China (National "973" program) [2011CBA00804]
WOS记录号WOS:000323203800009
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文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/15290
专题理论物理所SCI论文
通讯作者Zhang, YX (reprint author), Fudan Univ, Shanghai Key Lab Contemporary Appl Math, Ctr Computat Syst Biol, Sch Math Sci, Shanghai 200433, Peoples R China.
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GB/T 7714
Zhang, YX,Zhang, YX . Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule[J]. JOURNAL OF STATISTICAL PHYSICS,2013,152(6):1207-1221.
APA Zhang, YX,&Zhang, YX .(2013).Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule.JOURNAL OF STATISTICAL PHYSICS,152(6),1207-1221.
MLA Zhang, YX,et al."Theoretical Analysis of Kinesin KIF1A Transport Along Microtubule".JOURNAL OF STATISTICAL PHYSICS 152.6(2013):1207-1221.
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