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题名: Master equation approach for a cross-bridge power-stroke model with a finite number of motors
作者: Ma, R ;  Li, M ;  Ou-Yang, ZC ;  Shu, YG
刊名: PHYSICAL REVIEW E
出版日期: 2013
卷号: 87, 期号:5, 页码:52718
关键词: MOLECULAR MOTORS ;  ORGANELLE TRANSPORT ;  CARGO TRANSPORT ;  KINESIN ;  MUSCLE ;  CONTRACTION
学科分类: Physics
通讯作者: Ma, R (reprint author), Tsinghua Univ, Inst Adv Study, Beijing, Peoples R China.
部门归属: [Ma, Rui; Ou-Yang, Zhong-Can] Tsinghua Univ, Inst Adv Study, Beijing, Peoples R China; [Li, Ming] Univ Chinese Acad Sci, Sch Phys, Beijing, Peoples R China; [Ou-Yang, Zhong-Can; Shu, Yao-Gen] Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100080, Peoples R China
英文摘要: The cross-bridge power-stroke model has been widely used to describe the motion of large motor assemblies connected to a common rigid filament. In this paper, we go beyond the original velocity-ensemble approach and propose a master equation approach to account for the cooperative motion of a finite number of motors based on the cross-bridge model. By studying the force-velocity relationship for motors with strain-independent detachment rate, we show the convergence of our approach to the velocity-ensemble approach in the limit of large motor numbers. In the case that the detachment rate of motors is strain dependent, based on two assumptions for the strain distribution among motors, we show the occurrence of the bimodal distribution of the number of motors bound to the filament. This provides a new perspective to look at the instability of a multimotor system, which is essential for all the experimentally observed complex motions displayed by a group of motors, such as hysteresis, bidirectional motion, and spontaneous oscillation. By comparing the velocities calculated using the two assumptions with the stochastic simulation, it suggests that the coupling between motors via the common connection to the filament might facilitate the fast movement of filaments at small loading forces.
资助者: National Basic Research Program of China (973 program) [2013CB932804]; National Natural Science Foundation of China [91027045, 11075015]
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000319738000012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/15357
Appears in Collections:理论物理所2013年知识产出 _期刊论文

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Recommended Citation:
Ma, R,Li, M,Ou-Yang, ZC,et al. Master equation approach for a cross-bridge power-stroke model with a finite number of motors[J]. PHYSICAL REVIEW E,2013,87(5):52718.
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