Knowledge Management System of Institute of Theoretical Physics, CAS
Zhang, XH; Li, M![]() ![]() ![]() | |
Formation and dissociation of protonated cytosine-cytosine base pairs in i-motifs by ab initio quantum chemical calculations | |
发表期刊 | CHINESE PHYSICS B
![]() |
语种 | 英语 |
关键词 | Crystal-structure Gas-phase Dna Dynamics Telomere Strand |
摘要 | Formation and dissociation mechanisms of C-C+ base pairs in acidic and alkaline environments are investigated, employing ab initio quantum chemical calculations. Our calculations suggest that, in an acidic environment, a cytosine monomer is first protonated and then dimerized with an unprotonated cytosine monomer to form a C-C+ base pair; in an alkaline environment, a protonated cytosine dimer is first unprotonated and then dissociated into two cytosine monomers. In addition, the force for detaching a C-C+ base pair was found to be inversely proportional to the distance between the two cytosine monomers. These results provide a microscopic mechanism to qualitatively explain the experimentally observed reversible formation and dissociation of i-motifs. |
2014 | |
ISSN | 1674-1056 |
卷号 | 23期号:2页码:20702 |
学科领域 | Physics |
DOI | 10.1088/1674-1056/23/2/020702 |
收录类别 | SCI |
项目资助者 | National Basic Research Program of China (973 Program) [2013CB932804]; National Natural Science Foundation of China [91227115, 11121403]; Hundred Talent Program of the Chinese Academy of Sciences (CAS) ; National Basic Research Program of China (973 Program) [2013CB932804]; National Natural Science Foundation of China [91227115, 11121403]; Hundred Talent Program of the Chinese Academy of Sciences (CAS) ; National Basic Research Program of China (973 Program) [2013CB932804]; National Natural Science Foundation of China [91227115, 11121403]; Hundred Talent Program of the Chinese Academy of Sciences (CAS) ; National Basic Research Program of China (973 Program) [2013CB932804]; National Natural Science Foundation of China [91227115, 11121403]; Hundred Talent Program of the Chinese Academy of Sciences (CAS) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.itp.ac.cn/handle/311006/15483 |
专题 | 理论物理所科研产出_SCI论文 |
通讯作者 | Wang, YT (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China. |
推荐引用方式 GB/T 7714 | Zhang, XH,Li, M,Wang, YT,et al. Formation and dissociation of protonated cytosine-cytosine base pairs in i-motifs by ab initio quantum chemical calculations[J]. CHINESE PHYSICS B,2014,23(2):20702. |
APA | Zhang, XH,Li, M,Wang, YT,Ouyang, ZC,&Wang, YT .(2014).Formation and dissociation of protonated cytosine-cytosine base pairs in i-motifs by ab initio quantum chemical calculations.CHINESE PHYSICS B,23(2),20702. |
MLA | Zhang, XH,et al."Formation and dissociation of protonated cytosine-cytosine base pairs in i-motifs by ab initio quantum chemical calculations".CHINESE PHYSICS B 23.2(2014):20702. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Formation and dissoc(713KB) | 开放获取 | 使用许可 | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论