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Care, BR; Carrivain, P; Forne, T; Victor, JM; Lesne, A; Lesne, A (reprint author), Univ Paris 06, CNRS UMR 7600, Lab Phys Theor Mat Condensee, F-75005 Paris, France.
Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics
Source PublicationCOMMUNICATIONS IN THEORETICAL PHYSICS
Language英语
KeywordCoil-globule Transition Polymer-chain Chromatin Physics Organization Collapse Locus
AbstractInvestigating average thermodynamic quantities is not sufficient to understand conformational transitions of a finite-size polymer. We propose that such transitions are better described in terms of the probability distribution of some finite-size order parameter, and the evolution of this distribution as a control parameter varies. We demonstrate this claim for the coil-globule transition of a linear polymer and its mapping onto a two-state model. In a biological context, polymer models delineate the physical constraints experienced by the genome at different levels of organization, from DNA to chromatin to chromosome. We apply our finite-size approach to the formation of plectonemes in a DNA segment submitted to an applied torque and the ensuing helix-coil transition that can be numerically observed, with a coexistence of the helix and coil states in a range of parameters. Polymer models are also essential to analyze recent in vivo experiments providing the frequency of pairwise contacts between genomic loci. The probability distribution of these contacts yields quantitative information on the conformational fluctuations of chromosome regions. The changes observed in the shape of the distribution when the cell type or the physiological conditions vary may reveal an epigenetic modulation of the conformational constraints experienced by the chromosomes.
2014
ISSN0253-6102
Volume62Issue:4Pages:607-616
Subject AreaPhysics
Indexed BySCI
Funding OrganizationFrench Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03]
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Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/15640
Collection理论物理所科研产出_SCI论文
Corresponding AuthorLesne, A (reprint author), Univ Paris 06, CNRS UMR 7600, Lab Phys Theor Mat Condensee, F-75005 Paris, France.
Recommended Citation
GB/T 7714
Care, BR,Carrivain, P,Forne, T,et al. Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2014,62(4):607-616.
APA Care, BR,Carrivain, P,Forne, T,Victor, JM,Lesne, A,&Lesne, A .(2014).Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics.COMMUNICATIONS IN THEORETICAL PHYSICS,62(4),607-616.
MLA Care, BR,et al."Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics".COMMUNICATIONS IN THEORETICAL PHYSICS 62.4(2014):607-616.
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