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Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics
Care, BR; Carrivain, P; Forne, T; Victor, JM; Lesne, A; Lesne, A (reprint author), Univ Paris 06, CNRS UMR 7600, Lab Phys Theor Mat Condensee, F-75005 Paris, France.
2014
发表期刊COMMUNICATIONS IN THEORETICAL PHYSICS
ISSN0253-6102
卷号62期号:4页码:607-616
摘要Investigating average thermodynamic quantities is not sufficient to understand conformational transitions of a finite-size polymer. We propose that such transitions are better described in terms of the probability distribution of some finite-size order parameter, and the evolution of this distribution as a control parameter varies. We demonstrate this claim for the coil-globule transition of a linear polymer and its mapping onto a two-state model. In a biological context, polymer models delineate the physical constraints experienced by the genome at different levels of organization, from DNA to chromatin to chromosome. We apply our finite-size approach to the formation of plectonemes in a DNA segment submitted to an applied torque and the ensuing helix-coil transition that can be numerically observed, with a coexistence of the helix and coil states in a range of parameters. Polymer models are also essential to analyze recent in vivo experiments providing the frequency of pairwise contacts between genomic loci. The probability distribution of these contacts yields quantitative information on the conformational fluctuations of chromosome regions. The changes observed in the shape of the distribution when the cell type or the physiological conditions vary may reveal an epigenetic modulation of the conformational constraints experienced by the chromosomes.
部门归属[Care, Bertrand R. ; Victor, Jean-Marc ; Lesne, Annick] Univ Paris 06, CNRS UMR 7600, Lab Phys Theor Mat Condensee, F-75005 Paris, France ; [Carrivain, Pascal] CNRS, UPR 1142, Inst Genet Humaine, Montpellier, France ; [Forne, Thierry ; Victor, Jean-Marc ; Lesne, Annick] Univ Montpellier, CNRS UMR 5535, Inst Genet Mol Montpellier, F-34059 Montpellier, France ; [Lesne, Annick] Chinese Acad Sci, Kavli Inst Theoret Phys China, Beijing 100190, Peoples R China ; [Care, Bertrand R. ; Carrivain, Pascal ; Forne, Thierry ; Victor, Jean-Marc ; Lesne, Annick] Univ Paris 06, CNRS, GDR 3536, F-75005 Paris, France
关键词Coil-globule Transition Polymer-chain Chromatin Physics Organization Collapse Locus
学科领域Physics
资助者French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03]
收录类别SCI
语种英语
资助者French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03] ; French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03]
WOS记录号WOS:000345826400018
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/15640
专题理论物理所SCI论文
通讯作者Lesne, A (reprint author), Univ Paris 06, CNRS UMR 7600, Lab Phys Theor Mat Condensee, F-75005 Paris, France.
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Care, BR,Carrivain, P,Forne, T,et al. Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2014,62(4):607-616.
APA Care, BR,Carrivain, P,Forne, T,Victor, JM,Lesne, A,&Lesne, A .(2014).Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics.COMMUNICATIONS IN THEORETICAL PHYSICS,62(4),607-616.
MLA Care, BR,et al."Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics".COMMUNICATIONS IN THEORETICAL PHYSICS 62.4(2014):607-616.
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