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题名: Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle
作者: Liu, YH ;  Chen, YB ;  Mao, W ;  Hu, L ;  Deng, LH ;  Xu, HQ
刊名: FRONTIERS OF PHYSICS
出版日期: 2014
卷号: 9, 期号:4, 页码:519-522
关键词: MEDIATED ENDOCYTOSIS ;  CELLULAR UPTAKE ;  CELLS ;  MECHANISM ;  SIZE
学科分类: Physics
DOI: 10.1007/s11467-014-0412-6
通讯作者: Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.
部门归属: [Liu, Yan-Hui ;  Xu, Hou-Qiang] Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China ;  [Liu, Yan-Hui ;  Chen, Ying-Bing ;  Mao, Wei ;  Hu, Lin] Guizhou Univ, Coll Sci, Soft Condensed Matter Lab, Guiyang 550025, Peoples R China ;  [Liu, Yan-Hui] Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China ;  [Deng, Lin-Hong] Changzhou Univ, Inst Biomed Engn & Hlth Sci, Changzhou 213164, Peoples R China ;  [Deng, Lin-Hong] Chongqing Univ, Bioengn Coll, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China
英文摘要: Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and the optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of receptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone.
资助者: National Natural Science Foundation of China [11047022, 11204045, 31360215]; Research Foundation from Ministry of Education of China [2012152]; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069]; Natural Science Foundation of Guizhou Province [J20122166]; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University)
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000341429900012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/15691
Appears in Collections:理论物理所2014年知识产出 _期刊论文

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Recommended Citation:
Liu, YH,Chen, YB,Mao, W,et al. Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle[J]. FRONTIERS OF PHYSICS,2014,9(4):519-522.
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