Zheng, WM (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China
Protein sequences as special heterogeneous sequences are rare in the amino acid sequence space. The specific sequential order of amino acids of a protein is essential to its 3D structure. On the whole, the correlation between sequence and structure of a protein is not so strong. How well would a protein sequence contain its structural information? How does a sequence determine its native structure? Keeping the globular proteins in mind, we discuss several problems from sequence to structure.