ITP OpenIR  > 理论物理所2014年知识产出
Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif
Xu, Y; Chen, H; Qu, YJ; Efremov, AK; Li, M; Ouyang, ZC; Liu, DS; Yan, J; Liu, DS (reprint author), Tsinghua Univ, Minist Educ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China.
2014
发表期刊CHINESE PHYSICS B
ISSN1674-1056
卷号23期号:6页码:68702
摘要The DNA i-motif is a quadruplex structure formed in tandem cytosine-rich sequences in slightly acidic conditions. Besides being considered as a building block of DNA nano-devices, it may also play potential roles in regulating chromosome stability and gene transcriptions. The stability of i-motif is crucial for these functions. In this work, we investigated the mechanical stability of a single i-motif formed in the human telomeric sequence 5'-(CCCTAA)(3)CCC, which revealed a novel pH and loading rate-dependent bimodal unfolding force distribution. Although the cause of the bimodal unfolding force species is not clear, we proposed a phenomenological model involving a direct unfolding favored at lower loading rate or higher pH value, which is subject to competition with another unfolding pathway through a mechanically stable intermediate state whose nature is yet to be determined. Overall, the unique mechano-chemical responses of i-motif-provide a new perspective to its stability, which may be useful to guide designing new i-motif-based DNA mechanical nano-devices.
部门归属[Xu Yue
关键词G-quadruplex Mechanical Stability Rna-polymerase Stranded-dna Double Helix B-dna Molecule Force Proteins Dynamics
学科领域Physics
资助者National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005] ; National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005] ; National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005] ; National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005]
DOI10.1088/1674-1056/23/6/068702
URL查看原文
收录类别SCI
语种英语
资助者National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005] ; National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005] ; National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005] ; National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005]
WOS记录号WOS:000338668200102
引用统计
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/15749
专题理论物理所2014年知识产出
通讯作者Liu, DS (reprint author), Tsinghua Univ, Minist Educ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China.
推荐引用方式
GB/T 7714
Xu, Y,Chen, H,Qu, YJ,et al. Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif[J]. CHINESE PHYSICS B,2014,23(6):68702.
APA Xu, Y.,Chen, H.,Qu, YJ.,Efremov, AK.,Li, M.,...&Liu, DS .(2014).Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif.CHINESE PHYSICS B,23(6),68702.
MLA Xu, Y,et al."Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif".CHINESE PHYSICS B 23.6(2014):68702.
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