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题名: Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif
作者: Xu, Y;  Chen, H;  Qu, YJ;  Efremov, AK;  Li, M;  Ouyang, ZC;  Liu, DS;  Yan, J
刊名: CHINESE PHYSICS B
出版日期: 2014
卷号: 23, 期号:6, 页码:68702
关键词: G-QUADRUPLEX ;  MECHANICAL STABILITY ;  RNA-POLYMERASE ;  STRANDED-DNA ;  DOUBLE HELIX ;  B-DNA ;  MOLECULE ;  FORCE ;  PROTEINS ;  DYNAMICS
学科分类: Physics
DOI: 10.1088/1674-1056/23/6/068702
通讯作者: Liu, DS (reprint author), Tsinghua Univ, Minist Educ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China.
部门归属: [Xu Yue
英文摘要: The DNA i-motif is a quadruplex structure formed in tandem cytosine-rich sequences in slightly acidic conditions. Besides being considered as a building block of DNA nano-devices, it may also play potential roles in regulating chromosome stability and gene transcriptions. The stability of i-motif is crucial for these functions. In this work, we investigated the mechanical stability of a single i-motif formed in the human telomeric sequence 5'-(CCCTAA)(3)CCC, which revealed a novel pH and loading rate-dependent bimodal unfolding force distribution. Although the cause of the bimodal unfolding force species is not clear, we proposed a phenomenological model involving a direct unfolding favored at lower loading rate or higher pH value, which is subject to competition with another unfolding pathway through a mechanically stable intermediate state whose nature is yet to be determined. Overall, the unique mechano-chemical responses of i-motif-provide a new perspective to its stability, which may be useful to guide designing new i-motif-based DNA mechanical nano-devices.
资助者: National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore [MOE2012-T3-1-001]; National Basic Research Program of China [2013CB932800]; Major Research Plan of the National Natural Science Foundation of China [91027046, 91027045]; Fundamental Research Funds for the Central Universities [2013121005]
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000338668200102
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/15749
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Recommended Citation:
Xu, Y,Chen, H,Qu, YJ,et al. Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif[J]. CHINESE PHYSICS B,2014,23(6):68702.
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