ITP OpenIR  > 理论物理所2015年知识产出
The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes
Zhang, XM; Dai, LR; Wang, AH; Wolk, C; Dobner, B; Brezesinski, G; Tang, YQ; Wang, XY; Li, JB; Li, JB (reprint author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
2015
发表期刊SCIENTIFIC REPORTS
卷号5期号:0页码:16559
文章类型Article
摘要Highly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were found in this study to be gentle and safe exogenous stimuli for the triggering of membrane tubules. A specific lipid system was internalized by NIH3T3 cells. Following cellular uptake, the constructed liposomes traveled towards the nucleus in aggregations and were gradually distributed into moving vesicles and tubules in the cytosol. The triggered tubules proceeded, retreated or fluctuated along the cytoskeleton and were highly dynamic, moving quickly (up to several microns per second), and breaking and fusing frequently. These elongated tubules could also fuse with one another, giving rise to polygonal membrane networks. These lipid systems, with the novel property of accelerating intracellular transport, provide a new paradigm for investigating cellular dynamics.
学科领域Science & Technology - Other Topics
资助者National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; China Postdoctoral Science Foundation [2012M520218] ; China Postdoctoral Science Foundation [2012M520218] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; China Postdoctoral Science Foundation [2012M520218] ; China Postdoctoral Science Foundation [2012M520218] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Basic Research Program of China (973 Program) [2013YQ160551]
DOIhttp://dx.doi.org/10.1038/srep16559
关键词[WOS]ENDOPLASMIC-RETICULUM ; GENE DELIVERY ; LIVING CELLS ; CATIONIC LIPOSOMES ; TRANSPORT ; LIPIDS ; MICROTUBULES ; TRAFFICKING ; BEHAVIOR ; PROTEIN
收录类别SCI
语种英语
资助者National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; China Postdoctoral Science Foundation [2012M520218] ; China Postdoctoral Science Foundation [2012M520218] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; China Postdoctoral Science Foundation [2012M520218] ; China Postdoctoral Science Foundation [2012M520218] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Basic Research Program of China (973 Program) [2013YQ160551]
WOS类目Multidisciplinary Sciences
引用统计
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/20797
专题理论物理所2015年知识产出
通讯作者Li, JB (reprint author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
推荐引用方式
GB/T 7714
Zhang, XM,Dai, LR,Wang, AH,et al. The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes[J]. SCIENTIFIC REPORTS,2015,5(0):16559.
APA Zhang, XM.,Dai, LR.,Wang, AH.,Wolk, C.,Dobner, B.,...&Li, JB .(2015).The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes.SCIENTIFIC REPORTS,5(0),16559.
MLA Zhang, XM,et al."The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes".SCIENTIFIC REPORTS 5.0(2015):16559.
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