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题名: The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes
作者: Zhang, XM;  Dai, LR;  Wang, AH;  Wolk, C;  Dobner, B;  Brezesinski, G;  Tang, YQ;  Wang, XY;  Li, JB
刊名: SCIENTIFIC REPORTS
出版日期: 2015
卷号: 5, 期号:0, 页码:16559
学科分类: Science & Technology - Other Topics
DOI: http://dx.doi.org/10.1038/srep16559
通讯作者: Li, JB (reprint author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
文章类型: Article
英文摘要: Highly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were found in this study to be gentle and safe exogenous stimuli for the triggering of membrane tubules. A specific lipid system was internalized by NIH3T3 cells. Following cellular uptake, the constructed liposomes traveled towards the nucleus in aggregations and were gradually distributed into moving vesicles and tubules in the cytosol. The triggered tubules proceeded, retreated or fluctuated along the cytoskeleton and were highly dynamic, moving quickly (up to several microns per second), and breaking and fusing frequently. These elongated tubules could also fuse with one another, giving rise to polygonal membrane networks. These lipid systems, with the novel property of accelerating intracellular transport, provide a new paradigm for investigating cellular dynamics.
类目[WOS]: Multidisciplinary Sciences
关键词[WOS]: ENDOPLASMIC-RETICULUM ;  GENE DELIVERY ;  LIVING CELLS ;  CATIONIC LIPOSOMES ;  TRANSPORT ;  LIPIDS ;  MICROTUBULES ;  TRAFFICKING ;  BEHAVIOR ;  PROTEIN
收录类别: SCI
项目资助者: National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ;  China Postdoctoral Science Foundation [2012M520218] ;  National Basic Research Program of China (973 Program) [2013YQ160551]
语种: 英语
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/20797
Appears in Collections:理论物理所2015年知识产出_期刊论文

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Recommended Citation:
Zhang, XM,Dai, LR,Wang, AH,et al. The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes[J]. SCIENTIFIC REPORTS,2015,5(0):16559.
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