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Zhang, XM; Dai, LR; Wang, AH; Wolk, C; Dobner, B; Brezesinski, G; Tang, YQ; Wang, XY; Li, JB; Li, JB (reprint author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes
Source PublicationSCIENTIFIC REPORTS
Language英语
AbstractHighly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were found in this study to be gentle and safe exogenous stimuli for the triggering of membrane tubules. A specific lipid system was internalized by NIH3T3 cells. Following cellular uptake, the constructed liposomes traveled towards the nucleus in aggregations and were gradually distributed into moving vesicles and tubules in the cytosol. The triggered tubules proceeded, retreated or fluctuated along the cytoskeleton and were highly dynamic, moving quickly (up to several microns per second), and breaking and fusing frequently. These elongated tubules could also fuse with one another, giving rise to polygonal membrane networks. These lipid systems, with the novel property of accelerating intracellular transport, provide a new paradigm for investigating cellular dynamics.
2015
Volume5Issue:0Pages:16559
Subject AreaScience & Technology - Other Topics
DOIhttp://dx.doi.org/10.1038/srep16559
Indexed BySCI
Funding OrganizationNational Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; National Natural Science foundation of China [21433010, 21320102004, 21273053, 21321063] ; China Postdoctoral Science Foundation [2012M520218] ; China Postdoctoral Science Foundation [2012M520218] ; China Postdoctoral Science Foundation [2012M520218] ; China Postdoctoral Science Foundation [2012M520218] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Basic Research Program of China (973 Program) [2013YQ160551] ; National Basic Research Program of China (973 Program) [2013YQ160551]
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Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/20797
Collection理论物理所科研产出_SCI论文
Corresponding AuthorLi, JB (reprint author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Zhang, XM,Dai, LR,Wang, AH,et al. The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes[J]. SCIENTIFIC REPORTS,2015,5(0):16559.
APA Zhang, XM.,Dai, LR.,Wang, AH.,Wolk, C.,Dobner, B.,...&Li, JB .(2015).The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes.SCIENTIFIC REPORTS,5(0),16559.
MLA Zhang, XM,et al."The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes".SCIENTIFIC REPORTS 5.0(2015):16559.
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