ITP OpenIR  > 理论物理所科研产出  > SCI论文
Chen, YB; Liu, YH; Zeng, Y; Mao, W; Hu, L; Mao, ZL; Xu, HQ; Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.
Optimal aspect ratio of endocytosed spherocylindrical nanoparticle
Source PublicationFRONTIERS OF PHYSICS
Language英语
KeywordCellular Uptake Depletion Effects Dimension Of Ligand-receptor Complex Elasticity Theory
AbstractRecent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.
2015
Volume10Issue:1Pages:116-120
Subject AreaPhysics
DOIhttp://dx.doi.org/10.1007/s11467-014-0444-y
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311]
Citation statistics
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/21104
Collection理论物理所科研产出_SCI论文
Corresponding AuthorLiu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.
Recommended Citation
GB/T 7714
Chen, YB,Liu, YH,Zeng, Y,et al. Optimal aspect ratio of endocytosed spherocylindrical nanoparticle[J]. FRONTIERS OF PHYSICS,2015,10(1):116-120.
APA Chen, YB.,Liu, YH.,Zeng, Y.,Mao, W.,Hu, L.,...&Liu, YH .(2015).Optimal aspect ratio of endocytosed spherocylindrical nanoparticle.FRONTIERS OF PHYSICS,10(1),116-120.
MLA Chen, YB,et al."Optimal aspect ratio of endocytosed spherocylindrical nanoparticle".FRONTIERS OF PHYSICS 10.1(2015):116-120.
Files in This Item:
File Name/Size DocType Version Access License
Optimal aspect ratio(335KB)期刊论文出版稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, YB]'s Articles
[Liu, YH]'s Articles
[Zeng, Y]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, YB]'s Articles
[Liu, YH]'s Articles
[Zeng, Y]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, YB]'s Articles
[Liu, YH]'s Articles
[Zeng, Y]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.