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Optimal aspect ratio of endocytosed spherocylindrical nanoparticle
Chen, YB; Liu, YH; Zeng, Y; Mao, W; Hu, L; Mao, ZL; Xu, HQ; Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.
2015
发表期刊FRONTIERS OF PHYSICS
卷号10期号:1页码:116-120
文章类型Article
摘要Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.
关键词Cellular Uptake Depletion Effects Dimension Of Ligand-receptor Complex Elasticity Theory
学科领域Physics
资助者National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311]
DOIhttp://dx.doi.org/10.1007/s11467-014-0444-y
关键词[WOS]RECEPTOR-MEDIATED ENDOCYTOSIS ; CELLS ; MECHANICS ; SHAPES
收录类别SCI
语种英语
资助者National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 31360215] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Research Foundation from Ministry of Education of China [2012152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311]
WOS类目Physics, Multidisciplinary
引用统计
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/21104
专题理论物理所SCI论文
通讯作者Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.
推荐引用方式
GB/T 7714
Chen, YB,Liu, YH,Zeng, Y,et al. Optimal aspect ratio of endocytosed spherocylindrical nanoparticle[J]. FRONTIERS OF PHYSICS,2015,10(1):116-120.
APA Chen, YB.,Liu, YH.,Zeng, Y.,Mao, W.,Hu, L.,...&Liu, YH .(2015).Optimal aspect ratio of endocytosed spherocylindrical nanoparticle.FRONTIERS OF PHYSICS,10(1),116-120.
MLA Chen, YB,et al."Optimal aspect ratio of endocytosed spherocylindrical nanoparticle".FRONTIERS OF PHYSICS 10.1(2015):116-120.
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