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题名: Optimal aspect ratio of endocytosed spherocylindrical nanoparticle
作者: Chen, YB;  Liu, YH;  Zeng, Y;  Mao, W;  Hu, L;  Mao, ZL;  Xu, HQ
刊名: FRONTIERS OF PHYSICS
出版日期: 2015
卷号: 10, 期号:1, 页码:116-120
关键词: cellular uptake ;  depletion effects ;  dimension of ligand-receptor complex ;  elasticity theory
学科分类: Physics
DOI: http://dx.doi.org/10.1007/s11467-014-0444-y
通讯作者: Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.
文章类型: Article
英文摘要: Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.
类目[WOS]: Physics, Multidisciplinary
关键词[WOS]: RECEPTOR-MEDIATED ENDOCYTOSIS ;  CELLS ;  MECHANICS ;  SHAPES
收录类别: SCI
项目资助者: National Natural Science Foundation of China [11047022, 11204045, 31360215] ;  Research Foundation from Ministry of Education of China [2012152] ;  Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ;  Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) ;  Research Foundation for Young University Teachers from Guizhou University [201311]
语种: 英语
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/21104
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Recommended Citation:
Chen, YB,Liu, YH,Zeng, Y,et al. Optimal aspect ratio of endocytosed spherocylindrical nanoparticle[J]. FRONTIERS OF PHYSICS,2015,10(1):116-120.
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