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题名: Intrinsic defect formation in peptide self-assembly
作者: Deng, L;  Zhao, YR;  Xu, H;  Wang, YT
刊名: APPLIED PHYSICS LETTERS
出版日期: 2015
卷号: 107, 期号:4, 页码:43701
学科分类: Physics
DOI: http://dx.doi.org/10.1063/1.4927708
通讯作者: Xu, H (reprint author), China Univ Petr East China, Ctr Bioengn & Biotechnol, 66 Changjiang West Rd, Qingdao 266580, Peoples R China.
文章类型: Article
合作性质: 国内
英文摘要: In contrast to extensively studied defects in traditional materials, we report here a systematic investigation of the formation mechanism of intrinsic defects in self-assembled peptide nanostructures. The Monte Carlo simulations with our simplified dynamic hierarchical model revealed that the symmetry breaking of layer bending mode at the two ends during morphological transformation is responsible for intrinsic defect formation, whose microscopic origin is the mismatch between layer stacking along the side-chain direction and layer growth along the hydrogen bond direction. Moreover, defect formation does not affect the chirality of the self-assembled structure, which is determined by the initial steps of the peptide self-assembly process. (C) 2015 Author(s).
类目[WOS]: Physics, Applied
关键词[WOS]: AMYLOID FIBRIL ;  BETA-SHEETS ;  DISEASE ;  RIBBONS ;  MODEL
收录类别: SCI
项目资助者: National Basic Research Program of China (973 program) [2013CB932804] ;  National Natural Science Foundation of China [21373270, 91227115, 11421063] ;  Application Research Foundation for Post-doctoral Scientists of Qingdao [T1404096] ;  Program for New Century Excellent Talents in University [NCET-11-0735]
语种: 英语
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/21251
Appears in Collections:理论物理所计算集群成果_计算集群论文-标明致谢

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Recommended Citation:
Deng, L,Zhao, YR,Xu, H,et al. Intrinsic defect formation in peptide self-assembly[J]. APPLIED PHYSICS LETTERS,2015,107(4):43701.
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