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Advances in the mechanism of mechanochemical coupling of kinesin
Li, M; Ouyang, ZC; Shu, YG; Shu, YG (reprint author), Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China.; Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
2016
发表期刊ACTA PHYSICA SINICA
卷号65期号:18页码:188702
文章类型Article
摘要Kinesin is one of the most important linear motors for intracellular transport. It has two main features. One is its persistence: at least one head is attached to the microtubule during stepping, so that it can move a long distance before detaching. Another feature is the tight mechanochemical coupling: it consumes one adenosine-triphosphate for each step. Therefore, there should be a mechanism responsible for the coordination of the two heads to achieve the high persistence and tight coupling. The underlying mechanism is the mechanochemical coupling, which is the basic issue for all chemical-driven molecular motors. Owing to the developments of single-molecule experiments and molecular dynamics simulations, a breakthrough in the coupling mechanism has been made in recent decades. In this article, we review the progress of the relevant researches from the perspective of kinematics, energetics, coordination of two heads and force generating mechanism. We also present a personal perspective on the future studies of kinesin.
关键词Kinesin Single Molecule Technology Mechanochemical Coupling
学科领域Physics
资助者National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002]
DOIhttp://dx.doi.org/10.7498/aps.65.188702
关键词[WOS]BOVINE BRAIN KINESIN ; SQUID GIANT-AXON ; HAND-OVER-HAND ; NECK LINKER ; 8-NM STEP ; MOLECULAR MOTORS ; FORCE ; MICROSCOPY ; MOVEMENT ; MOTILITY
收录类别SCI
语种中文
资助者National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Basic Research Program of China [2013CB932804] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002] ; Joint NSFC-ISF Research Program [51561145002]
WOS类目Physics, Multidisciplinary
引用统计
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/21529
专题理论物理所SCI论文
通讯作者Shu, YG (reprint author), Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China.; Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
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Li, M,Ouyang, ZC,Shu, YG,et al. Advances in the mechanism of mechanochemical coupling of kinesin[J]. ACTA PHYSICA SINICA,2016,65(18):188702.
APA Li, M,Ouyang, ZC,Shu, YG,Shu, YG ,&Shu, YG .(2016).Advances in the mechanism of mechanochemical coupling of kinesin.ACTA PHYSICA SINICA,65(18),188702.
MLA Li, M,et al."Advances in the mechanism of mechanochemical coupling of kinesin".ACTA PHYSICA SINICA 65.18(2016):188702.
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