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题名: Advances in the mechanism of mechanochemical coupling of kinesin
作者: Li, M ;  Ouyang, ZC ;  Shu, YG
刊名: ACTA PHYSICA SINICA
出版日期: 2016
卷号: 65, 期号:18, 页码:188702
关键词: kinesin ;  single molecule technology ;  mechanochemical coupling
学科分类: Physics
DOI: http://dx.doi.org/10.7498/aps.65.188702
通讯作者: Shu, YG (reprint author), Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China. ;  Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
文章类型: Article
英文摘要: Kinesin is one of the most important linear motors for intracellular transport. It has two main features. One is its persistence: at least one head is attached to the microtubule during stepping, so that it can move a long distance before detaching. Another feature is the tight mechanochemical coupling: it consumes one adenosine-triphosphate for each step. Therefore, there should be a mechanism responsible for the coordination of the two heads to achieve the high persistence and tight coupling. The underlying mechanism is the mechanochemical coupling, which is the basic issue for all chemical-driven molecular motors. Owing to the developments of single-molecule experiments and molecular dynamics simulations, a breakthrough in the coupling mechanism has been made in recent decades. In this article, we review the progress of the relevant researches from the perspective of kinematics, energetics, coordination of two heads and force generating mechanism. We also present a personal perspective on the future studies of kinesin.
类目[WOS]: Physics, Multidisciplinary
关键词[WOS]: BOVINE BRAIN KINESIN ;  SQUID GIANT-AXON ;  HAND-OVER-HAND ;  NECK LINKER ;  8-NM STEP ;  MOLECULAR MOTORS ;  FORCE ;  MICROSCOPY ;  MOVEMENT ;  MOTILITY
收录类别: SCI
项目资助者: National Basic Research Program of China [2013CB932804] ;  National Natural Science Foundation of China [11574329, 11322543, 11105218] ;  Joint NSFC-ISF Research Program [51561145002]
语种: 中文
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/21529
Appears in Collections:理论物理所2016年知识产出_期刊论文

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Recommended Citation:
Li, M,Ouyang, ZC,Shu, YG. Advances in the mechanism of mechanochemical coupling of kinesin[J]. ACTA PHYSICA SINICA,2016,65(18):188702.
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