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Spike Pattern Structure Influences Synaptic Efficacy Variability under STDP and Synaptic Homeostasis. II: Spike Shuffling Methods on LIF Networks
Bi, ZD; Zhou, CS; Bi, ZD (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing, Peoples R China.; Zhou, CS (reprint author), Hong Kong Baptist Univ, Dept Phys, Kowloon Tong, Hong Kong, Peoples R China.; Zhou, CS (reprint author), Hong Kong Baptist Univ, Beijing Hong Kong Singapore Joint Ctr Nonlinear &, Ctr Nonlinear Studies, Inst Computat & Theoret Studies, Kowloon Tong, Hong Kong, Peoples R China.; Zhou, CS (reprint author), Beijing Computat Sci Res Ctr, Beijing, Peoples R China.; Zhou, CS (reprint author), Hong Kong Baptist Univ, Res Ctr, Inst Res & Continuing Educ, Shenzhen, Peoples R China.
2016
发表期刊FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
卷号10页码:83
文章类型Article
摘要Synapses may undergo variable changes during plasticity because of the variability of spike patterns such as temporal stochasticity and spatial randomness. Here, we call the variability of synaptic weight changes during plasticity to be efficacy variability. In this paper, we investigate how four aspects of spike pattern statistics (i.e., synchronous firing, burstiness/regularity, heterogeneity of rates and heterogeneity of cross-correlations) influence the efficacy variability under pair-wise additive spike-timing dependent plasticity (STDP) and synaptic homeostasis (the mean strength of plastic synapses into a neuron is bounded), by implementing spike shuffling methods onto spike patterns self-organized by a network of excitatory and inhibitory leaky integrate-and-fire (LIF) neurons. With the increase of the decay time scale of the inhibitory synaptic currents, the LIF network undergoes a transition from asynchronous state to weak synchronous state and then to synchronous bursting state. We first shuffle these spike patterns using a variety of methods, each designed to evidently change a specific pattern statistics; and then investigate the change of efficacy variability of the synapses under STDP and synaptic homeostasis, when the neurons in the network fire according to the spike patterns before and after being treated by a shuffling method. In this way, we can understand how the change of pattern statistics may cause the change of efficacy variability. Our results are consistent with those of our previous study which implements spike-generating models on converging motifs. We also find that burstiness/regularity is important to determine the efficacy variability under asynchronous states, while heterogeneity of cross-correlations is the main factor to cause efficacy variability when the network moves into synchronous bursting states (the states observed in epilepsy).
关键词Spike Pattern Structure Synaptic Plasticity Efficacy Variability Stdp Synaptic Homeostasis Spike Shuffling Methods
学科领域Mathematical & Computational Biology ; Neurosciences & Neurology
资助者Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027] ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027]
DOIhttp://dx.doi.org/10.3389/fncom.2016.00083
关键词[WOS]TIMING-DEPENDENT PLASTICITY ; GAMMA-OSCILLATIONS ; NEURAL-NETWORKS ; WORKING-MEMORY ; VISUAL-CORTEX ; FIRING RATES ; GABAERGIC INTERNEURONS ; CORTICAL NETWORKS ; CROSS-CORRELATION ; NEURONAL-ACTIVITY
收录类别SCI
语种英语
资助者Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027] ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; Hong Kong Baptist University (HKBU) Strategic Development Fund ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC-RGC Joint Research Scheme [HKUST/NSFC/12-13/01] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027] ; NSFC [11275027]
WOS类目Mathematical & Computational Biology ; Neurosciences
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文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/21567
专题理论物理所SCI论文
通讯作者Bi, ZD; Bi, ZD (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing, Peoples R China.; Zhou, CS (reprint author), Hong Kong Baptist Univ, Dept Phys, Kowloon Tong, Hong Kong, Peoples R China.; Zhou, CS (reprint author), Hong Kong Baptist Univ, Beijing Hong Kong Singapore Joint Ctr Nonlinear &, Ctr Nonlinear Studies, Inst Computat & Theoret Studies, Kowloon Tong, Hong Kong, Peoples R China.; Zhou, CS (reprint author), Beijing Computat Sci Res Ctr, Beijing, Peoples R China.; Zhou, CS (reprint author), Hong Kong Baptist Univ, Res Ctr, Inst Res & Continuing Educ, Shenzhen, Peoples R China.
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Bi, ZD,Zhou, CS,Bi, ZD ,et al. Spike Pattern Structure Influences Synaptic Efficacy Variability under STDP and Synaptic Homeostasis. II: Spike Shuffling Methods on LIF Networks[J]. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,2016,10:83.
APA Bi, ZD.,Zhou, CS.,Bi, ZD .,Zhou, CS .,Zhou, CS .,...&Zhou, CS .(2016).Spike Pattern Structure Influences Synaptic Efficacy Variability under STDP and Synaptic Homeostasis. II: Spike Shuffling Methods on LIF Networks.FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,10,83.
MLA Bi, ZD,et al."Spike Pattern Structure Influences Synaptic Efficacy Variability under STDP and Synaptic Homeostasis. II: Spike Shuffling Methods on LIF Networks".FRONTIERS IN COMPUTATIONAL NEUROSCIENCE 10(2016):83.
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