Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature

ITP OpenIR > 2016年知识产出

	Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature
	Mao, W; Liu, YH; Hu, L; Xu, HQ; Liu, YH (reprint author), Guizhou Univ, Coll Sci, Guiyang 550025, Peoples R China.; Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.; Liu, YH (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
	2016
发表期刊	COMMUNICATIONS IN THEORETICAL PHYSICS
卷号	65 期号:5 页码:639-644
文章类型	Article
摘要	DNA persistence length is a key parameter for quantitative interpretation of the conformational properties of DNA and related to the bending rigidity of DNA. A series of experiments pointed out that, in the DNA condensation process by multivalent cations, the condensed DNA takes elongated coil or compact globule states and the population of the compact globule states increases with an increase in ionic concentration. At the same time, single molecule experiments carried out in solution with multivalent cations (such as spermidine, spermine) indicated that DNA persistence length strongly depends on the ionic concentration. In order to revolve the effects of ionic concentration dependence of persistence length on DNA condensation, a model including the ionic concentration dependence of persistence length and strong correlation of multivalent cation on DNA is provided. The autocorrelation function of the tangent vectors is found as an effective way to detect the ionic concentration dependence of toroidal conformations. With an increase in ion concentration, the first periodic oscillation contained in the autocorrelation function shifts, the number of segment contained in the first periodic oscillation decreases gradually. According to the experiments, the average long-axis length is defined to estimate the ionic concentration dependence of condensation process further. The relation between long-axis length and ionic concentration matches the experimental results qualitatively.
关键词	Dna Condensation Monte Carlo Simulation Persistence Length Multivalent Cation
学科领域	Physics
资助者	National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; Research Foundation from Ministry of Education of China [212152] ; Research Foundation from Ministry of Education of China [212152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; West Light Foundation ; West Light Foundation ; College Innovation Talent Team of Guizhou Province [(2014) 32] ; College Innovation Talent Team of Guizhou Province [(2014) 32] ; National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; Research Foundation from Ministry of Education of China [212152] ; Research Foundation from Ministry of Education of China [212152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; West Light Foundation ; West Light Foundation ; College Innovation Talent Team of Guizhou Province [(2014) 32] ; College Innovation Talent Team of Guizhou Province [(2014) 32]
关键词[WOS]	SINGLE ; ELASTICITY ; TRANSITION ; MOLECULE
收录类别	SCI
语种	英语
资助者	National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; Research Foundation from Ministry of Education of China [212152] ; Research Foundation from Ministry of Education of China [212152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; West Light Foundation ; West Light Foundation ; College Innovation Talent Team of Guizhou Province [(2014) 32] ; College Innovation Talent Team of Guizhou Province [(2014) 32] ; National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ; Research Foundation from Ministry of Education of China [212152] ; Research Foundation from Ministry of Education of China [212152] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; Research Foundation for Young University Teachers from Guizhou University [201311] ; West Light Foundation ; West Light Foundation ; College Innovation Talent Team of Guizhou Province [(2014) 32] ; College Innovation Talent Team of Guizhou Province [(2014) 32]
WOS类目	Physics, Multidisciplinary
文献类型	期刊论文
条目标识符	http://ir.itp.ac.cn/handle/311006/21672
专题	2016年知识产出
通讯作者	Liu, YH (reprint author), Guizhou Univ, Coll Sci, Guiyang 550025, Peoples R China.; Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China.; Liu, YH (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Mao, W,Liu, YH,Hu, L,et al. Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2016,65(5):639-644.
APA	Mao, W.,Liu, YH.,Hu, L.,Xu, HQ.,Liu, YH .,...&Liu, YH .(2016).Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature.COMMUNICATIONS IN THEORETICAL PHYSICS,65(5),639-644.
MLA	Mao, W,et al."Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature".COMMUNICATIONS IN THEORETICAL PHYSICS 65.5(2016):639-644.

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