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题名: Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature
作者: Mao, W ;  Liu, YH ;  Hu, L ;  Xu, HQ
刊名: COMMUNICATIONS IN THEORETICAL PHYSICS
出版日期: 2016
卷号: 65, 期号:5, 页码:639-644
关键词: DNA condensation ;  Monte Carlo simulation ;  persistence length ;  multivalent cation
学科分类: Physics
通讯作者: Liu, YH (reprint author), Guizhou Univ, Coll Sci, Guiyang 550025, Peoples R China. ;  Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China. ;  Liu, YH (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
文章类型: Article
英文摘要: DNA persistence length is a key parameter for quantitative interpretation of the conformational properties of DNA and related to the bending rigidity of DNA. A series of experiments pointed out that, in the DNA condensation process by multivalent cations, the condensed DNA takes elongated coil or compact globule states and the population of the compact globule states increases with an increase in ionic concentration. At the same time, single molecule experiments carried out in solution with multivalent cations (such as spermidine, spermine) indicated that DNA persistence length strongly depends on the ionic concentration. In order to revolve the effects of ionic concentration dependence of persistence length on DNA condensation, a model including the ionic concentration dependence of persistence length and strong correlation of multivalent cation on DNA is provided. The autocorrelation function of the tangent vectors is found as an effective way to detect the ionic concentration dependence of toroidal conformations. With an increase in ion concentration, the first periodic oscillation contained in the autocorrelation function shifts, the number of segment contained in the first periodic oscillation decreases gradually. According to the experiments, the average long-axis length is defined to estimate the ionic concentration dependence of condensation process further. The relation between long-axis length and ionic concentration matches the experimental results qualitatively.
类目[WOS]: Physics, Multidisciplinary
关键词[WOS]: SINGLE ;  ELASTICITY ;  TRANSITION ;  MOLECULE
收录类别: SCI
项目资助者: National Natural Science Foundation of China [11047022, 11204045, 11464004, 31360215] ;  Research Foundation from Ministry of Education of China [212152] ;  Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069] ;  General Financial Grant from the China Postdoctoral Science Foundation [2014M562341] ;  Research Foundation for Young University Teachers from Guizhou University [201311] ;  West Light Foundation ;  College Innovation Talent Team of Guizhou Province [(2014) 32]
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/21672
Appears in Collections:理论物理所2016年知识产出_期刊论文

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Recommended Citation:
Mao, W,Liu, YH,Hu, L,et al. Effects of Ionic Dependence of DNA Persistence Length on the DNA Condensation at Room Temperature[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2016,65(5):639-644.
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