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Initiation Mechanism of Kinesin's Neck Linker Docking Process
Geng, YZ; Zhang, H; Lyu, G; Ji, Q; Ji, Q (reprint author), Hebei Univ Technol, Inst Biophys, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Hebei Univ Technol, Sch Sci, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
2017
发表期刊CHINESE PHYSICS LETTERS
卷号34期号:2页码:28701
文章类型Article
摘要The neck linker (NL) docking to the motor domain is the key force generation process of a kinesin motor. In the initiation step of NL docking the first three residues (LYS325, THR326 and ILE327 in 2KIN) of the NL must form an 'extra turn', thus the other parts of the NL could dock to the motor domain. How the extra turn is formed remains elusive. We investigate the extra turn formation mechanism using structure-based mechanical analysis via molecular dynamics simulation. We find that the motor head rotation induced by ATP binding first drives ILE327 to move towards a hydrophobic pocket on the motor domain. The driving force, together with the hydrophobic interaction of ILE327 with the hydrophobic pocket, then causes a clockwise rotation of THR326, breaks the locking of LYS325, and finally drives the extra turn formation. This extra turn formation mechanism provides a clear pathway from ATP binding to NL docking of kinesin.
学科领域Physics
资助者National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1]
DOIhttp://dx.doi.org/10.1088/0256-307X/34/2/028701
关键词[WOS]HAND-OVER-HAND ; MOLECULAR-DYNAMICS ; INTRACELLULAR-TRANSPORT ; MOTOR PROTEINS ; DOMAIN ; ACTIVATION ; BINDING ; FORCE
语种英语
资助者National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; National Natural Science Foundation of China [11545014, 11605038] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1] ; Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1]
WOS类目Physics, Multidisciplinary
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文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/22133
专题理论物理所SCI论文
通讯作者Ji, Q (reprint author), Hebei Univ Technol, Inst Biophys, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Hebei Univ Technol, Sch Sci, Tianjin 300401, Peoples R China.; Ji, Q (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
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GB/T 7714
Geng, YZ,Zhang, H,Lyu, G,et al. Initiation Mechanism of Kinesin's Neck Linker Docking Process[J]. CHINESE PHYSICS LETTERS,2017,34(2):28701.
APA Geng, YZ.,Zhang, H.,Lyu, G.,Ji, Q.,Ji, Q .,...&Ji, Q .(2017).Initiation Mechanism of Kinesin's Neck Linker Docking Process.CHINESE PHYSICS LETTERS,34(2),28701.
MLA Geng, YZ,et al."Initiation Mechanism of Kinesin's Neck Linker Docking Process".CHINESE PHYSICS LETTERS 34.2(2017):28701.
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