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题名: Initiation Mechanism of Kinesin's Neck Linker Docking Process
作者: Geng, YZ ;  Zhang, H ;  Lyu, G ;  Ji, Q
刊名: CHINESE PHYSICS LETTERS
出版日期: 2017
卷号: 34, 期号:2, 页码:28701
学科分类: Physics
DOI: http://dx.doi.org/10.1088/0256-307X/34/2/028701
通讯作者: Ji, Q (reprint author), Hebei Univ Technol, Inst Biophys, Tianjin 300401, Peoples R China. ;  Ji, Q (reprint author), Hebei Univ Technol, Sch Sci, Tianjin 300401, Peoples R China. ;  Ji, Q (reprint author), Chinese Acad Sci, Inst Theoret Phys, State Key Lab Theoret Phys, Beijing 100190, Peoples R China.
文章类型: Article
英文摘要: The neck linker (NL) docking to the motor domain is the key force generation process of a kinesin motor. In the initiation step of NL docking the first three residues (LYS325, THR326 and ILE327 in 2KIN) of the NL must form an 'extra turn', thus the other parts of the NL could dock to the motor domain. How the extra turn is formed remains elusive. We investigate the extra turn formation mechanism using structure-based mechanical analysis via molecular dynamics simulation. We find that the motor head rotation induced by ATP binding first drives ILE327 to move towards a hydrophobic pocket on the motor domain. The driving force, together with the hydrophobic interaction of ILE327 with the hydrophobic pocket, then causes a clockwise rotation of THR326, breaks the locking of LYS325, and finally drives the extra turn formation. This extra turn formation mechanism provides a clear pathway from ATP binding to NL docking of kinesin.
类目[WOS]: Physics, Multidisciplinary
关键词[WOS]: HAND-OVER-HAND ;  MOLECULAR-DYNAMICS ;  INTRACELLULAR-TRANSPORT ;  MOTOR PROTEINS ;  DOMAIN ;  ACTIVATION ;  BINDING ;  FORCE
项目资助者: National Natural Science Foundation of China [11545014, 11605038] ;  Open Project Program of State Key Laboratory of Theoretical Physics of Institute of Theoretical Physics of Chinese Academy of Science [Y5KF211CJ1]
语种: 英语
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/22133
Appears in Collections:理论物理所2017年知识产出_期刊论文

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Recommended Citation:
Geng, YZ,Zhang, H,Lyu, G,et al. Initiation Mechanism of Kinesin's Neck Linker Docking Process[J]. CHINESE PHYSICS LETTERS,2017,34(2):28701.
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