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Li, M![]() ![]() | |
Advances in the study of the mechanochemical coupling of kinesin | |
Source Publication | INTERNATIONAL JOURNAL OF MODERN PHYSICS B
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Language | 英语 |
Keyword | SQUID GIANT-AXON BOVINE BRAIN KINESIN HAND-OVER-HAND CRYSTAL-STRUCTURE MOTOR DOMAIN NECK LINKER 8-NM STEP MOLECULAR MOTORS OPTICAL-TRAP FORCE |
Abstract | Kinesin is a two-headed linear motor for intracellular transport. It can walk a long distance in a hand-over-hand manner along the track before detaching (i.e., high processivity), and it consumes one ATP molecule for each step (i.e., tight mechanochemical coupling). The mechanisms of the coordination of its two heads and the mechanochemical coupling are the central issues of numerous researches. A few advances have been made in recent decades, thanks to the development of single-molecule technologies and molecular dynamics simulations. In this paper, we review some progress of the studies on the kinematics, energetics, coordination mechanism, mechanochemical mechanism of kinesin. We also present a personal perspective on the future studies of kinesin. |
2018 | |
ISSN | 0217-9792 |
Volume | 32Issue:18Pages:1840001 |
Subject Area | Physics |
MOST Discipline Catalogue | Physics, Applied ; Physics, Condensed Matter ; Physics, Mathematical |
DOI | 10.1142/S0217979218400015 |
Indexed By | SCIE |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.itp.ac.cn/handle/311006/22856 |
Collection | SCI期刊论文 |
Affiliation | 1.[Li, Ming 2.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China 3.[Ou-Yang, Zhong-Can 4.Chinese Acad Sci, Inst Theoret Phys, CAS Key Lab Theoret Phys, Beijing 100190, Peoples R China |
Recommended Citation GB/T 7714 | Li, M,Ou-Yang, ZC,Shu, YG. Advances in the study of the mechanochemical coupling of kinesin[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2018,32(18):1840001. |
APA | Li, M,Ou-Yang, ZC,&Shu, YG.(2018).Advances in the study of the mechanochemical coupling of kinesin.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,32(18),1840001. |
MLA | Li, M,et al."Advances in the study of the mechanochemical coupling of kinesin".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 32.18(2018):1840001. |
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Advances in the mech(1300KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | Application Full Text |
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