Advances in the study of the mechanochemical coupling of kinesin

doi:10.1142/S0217979218400015

ITP OpenIR > SCI期刊论文

	Li, M; Ou-Yang, ZC; Shu, YG
	Advances in the study of the mechanochemical coupling of kinesin
Source Publication	INTERNATIONAL JOURNAL OF MODERN PHYSICS B
Language	英语
Keyword	SQUID GIANT-AXON BOVINE BRAIN KINESIN HAND-OVER-HAND CRYSTAL-STRUCTURE MOTOR DOMAIN NECK LINKER 8-NM STEP MOLECULAR MOTORS OPTICAL-TRAP FORCE
Abstract	Kinesin is a two-headed linear motor for intracellular transport. It can walk a long distance in a hand-over-hand manner along the track before detaching (i.e., high processivity), and it consumes one ATP molecule for each step (i.e., tight mechanochemical coupling). The mechanisms of the coordination of its two heads and the mechanochemical coupling are the central issues of numerous researches. A few advances have been made in recent decades, thanks to the development of single-molecule technologies and molecular dynamics simulations. In this paper, we review some progress of the studies on the kinematics, energetics, coordination mechanism, mechanochemical mechanism of kinesin. We also present a personal perspective on the future studies of kinesin.
	2018
ISSN	0217-9792
Volume	32 Issue:18 Pages:1840001
Subject Area	Physics
MOST Discipline Catalogue	Physics, Applied ; Physics, Condensed Matter ; Physics, Mathematical
DOI	10.1142/S0217979218400015
Indexed By	SCIE
Citation statistics	Cited Times:2[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.itp.ac.cn/handle/311006/22856
Collection	SCI期刊论文
Affiliation	1.[Li, Ming 2.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China 3.[Ou-Yang, Zhong-Can 4.Chinese Acad Sci, Inst Theoret Phys, CAS Key Lab Theoret Phys, Beijing 100190, Peoples R China
Recommended Citation GB/T 7714	Li, M,Ou-Yang, ZC,Shu, YG. Advances in the study of the mechanochemical coupling of kinesin[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2018,32(18):1840001.
APA	Li, M,Ou-Yang, ZC,&Shu, YG.(2018).Advances in the study of the mechanochemical coupling of kinesin.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,32(18),1840001.
MLA	Li, M,et al."Advances in the study of the mechanochemical coupling of kinesin".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 32.18(2018):1840001.

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