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Wu, D; Jose, JV; Nurnberger, JI; Torres, EB
A Biomarker Characterizing Neurodevelopment with applications in Autism
Source PublicationSCIENTIFIC REPORTS
Language英语
KeywordSPECTRUM DISORDERS COMPUTATIONAL PSYCHIATRY ARM MOVEMENTS CHILDREN NEUROSCIENCE PHENOTYPE BEHAVIOR RISK
AbstractDespite great advances in neuroscience and genetic studies, our understanding of neurodevelopmental disorders is still quite limited. An important reason is not having objective psychiatric clinical tests. Here we propose a quantitative neurodevelopment assessment by studying natural movement outputs. Movement is central to behaviors: It involves complex coordination, temporal alterations, and precise dynamic controls. We carefully analyzed the continuous movement output data, collected with high definition electromagnetic sensors at millisecond time scales. We unraveled new metrics containing striking physiological information that was unseen neither by using traditional motion assessments nor by naked eye observations. Our putative biomarker leads to precise individualized classifications. It illustrates clear differences between Autism Spectrum Disorder (ASD) subjects from mature typical developing (TD) individuals. It provides an ASD complementary quantitative classification, which closely agrees with the clinicaly assessed functioning levels in the spectrum. It also illustrates TD potential age-related neurodevelopmental trajectories. Applying our movement biomarker to the parents of the ASD individuals studied in the cohort also shows a novel potential familial signature ASD tie. This paper proposes a putative behavioral biomarker to characterize the level of neurodevelopment with high predicting power, as illustrated in ASD subjects as an example.
2018
ISSN2045-2322
Volume8Pages:614
Subject AreaScience & Technology - Other Topics
MOST Discipline CatalogueMultidisciplinary Sciences
DOI10.1038/s41598-017-18902-w
Indexed BySCIE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/22982
Collection理论物理所科研产出_SCI论文
Affiliation1.[Wu, Di
2.Jose, Jorge V.] Indiana Univ, Dept Phys, Bloomington, IN 47405 USA
3.[Jose, Jorge V.] Indiana Univ Sch Med, Stark Neurosci Inst, Indianapolis, IN 46202 USA
4.[Jose, Jorge V.] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA
5.Jose, Jorge V.] Chinese Acad Sci, Inst Theoret Phys, Key Lab Theoret Phys, Beijing, Peoples R China
6.[Nurnberger, John I.] Indiana Univ Sch Med, Inst Psychiat Res, Dept Psychiat, Indianapolis, IN 46202 USA
7.[Torres, Elizabeth B.] Rutgers State Univ, Psychol Dept, New Brunswick, NJ USA
8.[Torres, Elizabeth B.] Rutgers State Univ, Rutgers Ctr Cognit Sci, New Brunswick, NJ USA
9.[Torres, Elizabeth B.] Rutgers State Univ, Ctr Biomed Imaging & Modeling, Comp Sci Dept, New Brunswick, NJ USA
Recommended Citation
GB/T 7714
Wu, D,Jose, JV,Nurnberger, JI,et al. A Biomarker Characterizing Neurodevelopment with applications in Autism[J]. SCIENTIFIC REPORTS,2018,8:614.
APA Wu, D,Jose, JV,Nurnberger, JI,&Torres, EB.(2018).A Biomarker Characterizing Neurodevelopment with applications in Autism.SCIENTIFIC REPORTS,8,614.
MLA Wu, D,et al."A Biomarker Characterizing Neurodevelopment with applications in Autism".SCIENTIFIC REPORTS 8(2018):614.
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