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Li, M; Ouyang, ZC; Shu, YG
Advances in the mechanism of mechanochemical coupling of kinesin
Source PublicationACTA PHYSICA SINICA
Language中文
Keywordkinesin BOVINE BRAIN KINESIN single molecule technology SQUID GIANT-AXON mechanochemical coupling HAND-OVER-HAND NECK LINKER 8-NM STEP MOLECULAR MOTORS FORCE MICROSCOPY MOVEMENT MOTILITY
AbstractKinesin is one of the most important linear motors for intracellular transport. It has two main features. One is its persistence: at least one head is attached to the microtubule during stepping, so that it can move a long distance before detaching. Another feature is the tight mechanochemical coupling: it consumes one adenosine-triphosphate for each step. Therefore, there should be a mechanism responsible for the coordination of the two heads to achieve the high persistence and tight coupling. The underlying mechanism is the mechanochemical coupling, which is the basic issue for all chemical-driven molecular motors. Owing to the developments of single-molecule experiments and molecular dynamics simulations, a breakthrough in the coupling mechanism has been made in recent decades. In this article, we review the progress of the relevant researches from the perspective of kinematics, energetics, coordination of two heads and force generating mechanism. We also present a personal perspective on the future studies of kinesin.
2016
Volume65Issue:18Pages:188702
Subject AreaPhysics
DOIhttp://dx.doi.org/10.7498/aps.65.188702
Indexed BySCI
Funding OrganizationNational Basic Research Program of China [2013CB932804] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; Joint NSFC-ISF Research Program [51561145002]
Citation statistics
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/23031
Collection理论物理所科研产出_SCI论文
Affiliation1.[Li Ming
2.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China
3.[Ouyang Zhong-Can
4.Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, M,Ouyang, ZC,Shu, YG. Advances in the mechanism of mechanochemical coupling of kinesin[J]. ACTA PHYSICA SINICA,2016,65(18):188702.
APA Li, M,Ouyang, ZC,&Shu, YG.(2016).Advances in the mechanism of mechanochemical coupling of kinesin.ACTA PHYSICA SINICA,65(18),188702.
MLA Li, M,et al."Advances in the mechanism of mechanochemical coupling of kinesin".ACTA PHYSICA SINICA 65.18(2016):188702.
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