Behaviors of Glioblastoma Cells in in Vitro Microenvironments

doi:10.1038/s41598-018-36347-7

ITP OpenIR > SCI期刊论文

	Diao, WW ; Tong, XZ ; Yang, C 3,4; Zhang, FR ; Bao, C 5,6,7; Chen, H 5,6,7; Liu, LY ; Li, M3,4 ; Ye, FF ; Fan, QH ; Wang, JF ; Ou-Yang, ZC
	Behaviors of Glioblastoma Cells in in Vitro Microenvironments
Source Publication	SCIENTIFIC REPORTS
Language	英语
Keyword	MATRIX GLIOMA MIGRATION BRAIN MORPHOGENESIS INCREASE GROWTH CANCER
Abstract	Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus allows the GBM cells to grow in the 3-D chambers. The GBM cells in this model showed specific properties on the aspects of cell morphology, proliferation, migration, and invasion, some of which were rarely observed before. Furthermore, how the cells invaded into the surrounding ECM and the corresponding specific invasion patterns were observed in details, implying that the four types of cells have different features during their development in cancer. This complex in vitro model, if applied to patient derived cells, possesses the potential of becoming a clinically relevant predictive model.
	2019
ISSN	2045-2322
Volume	9 Pages:85
Subject Area	Science & Technology - Other Topics
MOST Discipline Catalogue	Multidisciplinary Sciences
DOI	10.1038/s41598-018-36347-7
Indexed By	SCIE
Citation statistics	Cited Times:5[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.itp.ac.cn/handle/311006/23509
Collection	SCI期刊论文
Affiliation	1.Chinese Acad Sci, Inst Theoret Phys, Key Lab Theoret Phys, 55 East Zhongguancun Rd, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Phys Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China 4.Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Phys, CAS Key Lab Soft Matter Phys, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325001, Peoples R China 7.Wenzhou Med Univ, Sch Optometry & Ophthalmol, Wenzhou 325027, Peoples R China 8.Wenzhou Med Univ, Eye Hosp, Wenzhou 325027, Peoples R China 9.Chongqing Univ, Coll Phys, Chongqing 401331, Peoples R China
Recommended Citation GB/T 7714	Diao, WW,Tong, XZ,Yang, C,et al. Behaviors of Glioblastoma Cells in in Vitro Microenvironments[J]. SCIENTIFIC REPORTS,2019,9:85.
APA	Diao, WW.,Tong, XZ.,Yang, C.,Zhang, FR.,Bao, C.,...&Ou-Yang, ZC.(2019).Behaviors of Glioblastoma Cells in in Vitro Microenvironments.SCIENTIFIC REPORTS,9,85.
MLA	Diao, WW,et al."Behaviors of Glioblastoma Cells in in Vitro Microenvironments".SCIENTIFIC REPORTS 9(2019):85.

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