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Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S
Yong, Y; Dai, LR; Iwamoto, M; Ou-Yang, ZC
2006
Conference Name6th International Conference on Nano-Molecular Electronics (ICNME2004)
Source PublicationTHIN SOLID FILMS
Volume499
Issue1-2
Pages224-228
Conference DateDEC 15-17, 2004
Conference PlaceKobe, JAPAN
Publication PlaceLAUSANNE
ISSN0040-6090
PublisherELSEVIER SCIENCE SA
AbstractThe single point mutation F198S in prion protein can induce aberrant 3-dimensional structure which finally lead to serious disease. One of the most significant differences between normal and abnormal structures is the concentration of alpha-helix and beta-sheet. By employing molecular dynamics method, we studied the structural transition induced by the mutation F198S. Our results show that the loss of the hydrophobic interactions between the 198-th residue and its surroundings may lead to the transition. A creation of additional beta-sheet is captured in our investigation which has not been reported in the dynamical studies of mutated induced structure conversion in prion protein. (c) 2005 Elsevier B.V All rights reserved.
KeywordPROTEIN THERMODYNAMICS SIMULATION CONVERSION FEATURES MODEL
DOI10.1016/j.tsf.2005.07.008
URL查看原文
Indexed ByCPCI
Language英语
WOS Research AreaMaterials Science ; Physics
WOS SubjectMaterials Science, Multidisciplinary ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type会议论文
Identifierhttp://ir.itp.ac.cn/handle/311006/23692
CollectionSCI会议论文
Affiliation1.Chinese Acad Sci, Interdisciplinary Ctr Theoret Studies, Beijing 100864, Peoples R China
2.Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
3.Tokyo Inst Technol, Dept Phys Elect, Meguro Ku, Tokyo 1528552, Japan
4.Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Yong, Y,Dai, LR,Iwamoto, M,et al. Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S[C]. LAUSANNE:ELSEVIER SCIENCE SA,2006:224-228.
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