ITP OpenIR  > SCI期刊论文
Zhang, Zhichao1; Zhang, Qing1; Guan, Shaohua1; Shi, Hualin1
Quantitative Connection between Cell Size and Growth Rate by Phospholipid Metabolism
Source PublicationCELLS
Language英语
KeywordHAEMOPHILUS-INFLUENZAE RD GRAM-NEGATIVE BACTERIA ESCHERICHIA-COLI OUTER-MEMBRANE FATTY-ACID GUANOSINE TETRAPHOSPHATE CARDIOLIPIN SYNTHASE ADAPTIVE EVOLUTION ENVELOPE MODEL
AbstractThe processes involved in cell growth are extremely complicated even for a single cell organism such as Escherichia coli, while the relationship between growth rate and cell size is simple. We aimed to reveal the systematic link between them from the aspect of the genome-scale metabolic network. Since the growth rate reflects metabolic rates of bacteria and the cell size relates to phospholipid synthesis, a part of bacterial metabolic networks, we calculated the cell length from the cardiolipin synthesis rate, where the cardiolipin synthesis reaction is able to represent the phospholipid metabolism of Escherichia coli in the exponential growth phase. Combined with the flux balance analysis, it enables us to predict cell length and to examine the quantitative relationship between cell length and growth rate. By simulating bacteria growing in various nutrient media with the flux balance analysis and calculating the corresponding cell length, we found that the increase of the synthesis rate of phospholipid, the cell width, and the protein fraction in membranes caused the increase of cell length with growth rate. Different tendencies of phospholipid synthesis rate changing with growth rate result in different relationships between cell length and growth rate. The effects of gene deletions on cell size and growth rate are also examined. Knocking out the genes, such as Delta tktA, Delta tktB, Delta yqaB, Delta pgm, and Delta cysQ, affects growth rate largely while affecting cell length slightly. Results of this method are in good agreement with experiments.
2020
Volume9Issue:2Pages:391
Cooperation Status国内
Subject AreaCell Biology
MOST Discipline CatalogueCell Biology
DOI10.3390/cells9020391
Indexed BySCIE
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/27074
CollectionSCI期刊论文
Affiliation1.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Theoret Phys, CAS Key Lab Theoret Phys, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhichao,Zhang, Qing,Guan, Shaohua,et al. Quantitative Connection between Cell Size and Growth Rate by Phospholipid Metabolism[J]. CELLS,2020,9(2):391.
APA Zhang, Zhichao,Zhang, Qing,Guan, Shaohua,&Shi, Hualin.(2020).Quantitative Connection between Cell Size and Growth Rate by Phospholipid Metabolism.CELLS,9(2),391.
MLA Zhang, Zhichao,et al."Quantitative Connection between Cell Size and Growth Rate by Phospholipid Metabolism".CELLS 9.2(2020):391.
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