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Guan, Shaohua1; Xu, Liufang2,3; Zhang, Qing; Shi, Hualin1
Trade-offs between effectiveness and cost in bifunctional enzyme circuit with concentration robustness
Source PublicationPHYSICAL REVIEW E
Language英语
KeywordCHEMICAL-SYSTEMS GENE-EXPRESSION PHOSPHORYLATION NOISE ORIGINS GROWTH SPEED OMPR ATP
AbstractA fundamental trade-off in biological systems is whether they consume resources to perform biological functions or save resources. Bacteria need to reliably and rapidly respond to input signals by using limited cellular resources. However, excessive resource consumption will become a burden for bacteria growth. To investigate the relationship between functional effectiveness and resource cost, we study the ubiquitous bifunctional enzyme circuit, which is robust to fluctuations in protein concentration and responds quickly to signal changes. We show that trade-off relationships exist between functional effectiveness and protein cost. Expressing more proteins of the circuit increases concentration robustness and response speed but affects bacterial growth. In particular, our study reveals a general relationship between free-energy dissipation rate, response speed, and concentration robustness. The dissipation of free energy plays an important role in the concentration robustness and response speed. High robustness can only be achieved with a large amount of free-energy consumption and protein cost. In addition, the noise of the output increases with increasing protein cost, while the noise of the response time decreases with increasing protein cost. We also calculate the trade-off relationships in the EnvZ-OmpR system and the nitrogen assimilation system, which both have the bifunctional enzyme. Similar results indicate that these relationships are mainly derived from the specific feature of the bifunctional enzyme circuits and are not relevant to the details of the models. According to the trade-off relationships, bacteria take a compromise solution that reliably performs biological functions at a reasonable cost.
2020
ISSN2470-0045
Volume101Issue:1Pages:12409
Cooperation Status国内
Subject AreaPhysics
MOST Discipline CataloguePhysics, Fluids & Plasmas ; Physics, Mathematical
DOI10.1103/PhysRevE.101.012409
Indexed BySCIE
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Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/27120
CollectionSCI期刊论文
Affiliation1.Chinese Acad Sci, Inst Theoret Phys, CAS Key Lab Theoret Phys, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China
3.Jilin Univ, Dept Phys, Changchun 130012, Jilin, Peoples R China
4.Jilin Univ, Biophys & Complex Syst Ctr, Changchun 130012, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Guan, Shaohua,Xu, Liufang,Zhang, Qing,et al. Trade-offs between effectiveness and cost in bifunctional enzyme circuit with concentration robustness[J]. PHYSICAL REVIEW E,2020,101(1):12409.
APA Guan, Shaohua,Xu, Liufang,Zhang, Qing,&Shi, Hualin.(2020).Trade-offs between effectiveness and cost in bifunctional enzyme circuit with concentration robustness.PHYSICAL REVIEW E,101(1),12409.
MLA Guan, Shaohua,et al."Trade-offs between effectiveness and cost in bifunctional enzyme circuit with concentration robustness".PHYSICAL REVIEW E 101.1(2020):12409.
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