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Temperature dependence of circular DNA topological states
Chen, Hu; Liu, Yanhui; Zhou, Zhen; Hu, Lin; Ou-Yang, Zhong-Can; Yan, Jie; Chen, H , Natl Univ Singapore, Dept Phys, 2 Sci Dr 3, Singapore 117542, Singapore
2009
发表期刊PHYSICAL REVIEW E
ISSN1539-3755
卷号79期号:4页码:-
摘要Circular double-stranded DNA has different topological states which are defined by their linking numbers. Equilibrium distribution of linking numbers can be obtained by closing a linear DNA into a circle by ligase. Using Monte Carlo simulation, we predict the temperature dependence of the linking number distribution of small circular DNAs. Our predictions are based on flexible defect excitations that resulted from local melting or unstacking of DNA base pairs. We found that the reduced bending rigidity alone can lead to measurable changes of the variance of linking number distribution of short circular DNAs. If the defect is accompanied by local unwinding, the effect becomes much more prominent. The predictions can be easily investigated in experiments, providing a new method to study the micromechanics of sharply bent DNAs and the thermal stability of specific DNA sequences. Furthermore, the predictions are directly applicable to the studies of binding of DNA-distorting proteins that can locally reduce DNA rigidity, form DNA kinks, or introduce local unwinding.
部门归属[Chen, H; Liu, YH; Zhou, Z; Yan, J] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore; [Liu, YH; Hu, L] Guizhou Univ, Guizhou Prov Key Lab Photoelect Technol & Appllic, Guiyang 550025, Peoples R China; [Liu, YH; Ou-Yang, ZC] Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Double Helix Entropic Elasticity Free-energy Cyclization Fluctuations Simulations Kinking Length Twist
学科领域Physics
资助者Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences ; Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences ; Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences ; Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences
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收录类别SCI
资助者Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences ; Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences ; Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences ; Ministry of Education of Singapore[R144000143112, R144000171101]; Chinese Academy of Sciences
WOS记录号WOS:000265941300120
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/5350
专题理论物理所1978-2010年知识产出
通讯作者Chen, H , Natl Univ Singapore, Dept Phys, 2 Sci Dr 3, Singapore 117542, Singapore
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GB/T 7714
Chen, Hu,Liu, Yanhui,Zhou, Zhen,et al. Temperature dependence of circular DNA topological states[J]. PHYSICAL REVIEW E,2009,79(4):-.
APA Chen, Hu.,Liu, Yanhui.,Zhou, Zhen.,Hu, Lin.,Ou-Yang, Zhong-Can.,...&Chen, H , Natl Univ Singapore, Dept Phys, 2 Sci Dr 3, Singapore 117542, Singapore.(2009).Temperature dependence of circular DNA topological states.PHYSICAL REVIEW E,79(4),-.
MLA Chen, Hu,et al."Temperature dependence of circular DNA topological states".PHYSICAL REVIEW E 79.4(2009):-.
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