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Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs
Xue, Xiao Chuan; Tong, Huan; Liu, Fei; Ou-Yang, Zhong-can; Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
2008
发表期刊JOURNAL OF PHYSICAL CHEMISTRY B
ISSN1520-6106
卷号112期号:44页码:13680-13683
摘要On the basis of a coarse-grain physical model of the folding and unfolding of single-forced RNAs conducted in light tweezer experiments, we theoretically investigate the feasibility of inferring the RNA's intrinsic kinetic parameters from the noisy time series of the molecule's extension. A Bayesian approach using Monte Carlo Markov Chain is proposed. We prove that this statistical approach is efficient and accurate in inferring the molecule's physical parameters, even if the experimental data are yielded under a narrow range of forces.
部门归属[Xue, XC; Tong, H; Liu, F; Ou-Yang, ZC] Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; [Ou-Yang, ZC] Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Optical Tweezers Kinetics Models Dna
学科领域Physics
资助者Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045]
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收录类别SCI
资助者Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045]
WOS记录号WOS:000260533100003
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文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/5440
专题理论物理所SCI论文
通讯作者Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
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GB/T 7714
Xue, Xiao Chuan,Tong, Huan,Liu, Fei,et al. Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(44):13680-13683.
APA Xue, Xiao Chuan,Tong, Huan,Liu, Fei,Ou-Yang, Zhong-can,&Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2008).Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs.JOURNAL OF PHYSICAL CHEMISTRY B,112(44),13680-13683.
MLA Xue, Xiao Chuan,et al."Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs".JOURNAL OF PHYSICAL CHEMISTRY B 112.44(2008):13680-13683.
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