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Xue, Xiao Chuan; Tong, Huan; Liu, Fei; Ou-Yang, Zhong-can; Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs
Source PublicationJOURNAL OF PHYSICAL CHEMISTRY B
KeywordOptical Tweezers Kinetics Models Dna
AbstractOn the basis of a coarse-grain physical model of the folding and unfolding of single-forced RNAs conducted in light tweezer experiments, we theoretically investigate the feasibility of inferring the RNA's intrinsic kinetic parameters from the noisy time series of the molecule's extension. A Bayesian approach using Monte Carlo Markov Chain is proposed. We prove that this statistical approach is efficient and accurate in inferring the molecule's physical parameters, even if the experimental data are yielded under a narrow range of forces.
2008
ISSN1520-6106
Volume112Issue:44Pages:13680-13683
Subject AreaPhysics
Indexed BySCI
Funding OrganizationTsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045]
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/5440
Collection理论物理所科研产出_SCI论文
Corresponding AuthorLiu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Xue, Xiao Chuan,Tong, Huan,Liu, Fei,et al. Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(44):13680-13683.
APA Xue, Xiao Chuan,Tong, Huan,Liu, Fei,Ou-Yang, Zhong-can,&Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2008).Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs.JOURNAL OF PHYSICAL CHEMISTRY B,112(44),13680-13683.
MLA Xue, Xiao Chuan,et al."Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs".JOURNAL OF PHYSICAL CHEMISTRY B 112.44(2008):13680-13683.
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