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题名: Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs
作者: Xue, Xiao Chuan ;  Tong, Huan ;  Liu, Fei ;  Ou-Yang, Zhong-can
刊名: JOURNAL OF PHYSICAL CHEMISTRY B
出版日期: 2008
卷号: 112, 期号:44, 页码:13680-13683
关键词: OPTICAL TWEEZERS ;  KINETICS ;  MODELS ;  DNA
学科分类: Physics
通讯作者: Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
部门归属: [Xue, XC; Tong, H; Liu, F; Ou-Yang, ZC] Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; [Ou-Yang, ZC] Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: On the basis of a coarse-grain physical model of the folding and unfolding of single-forced RNAs conducted in light tweezer experiments, we theoretically investigate the feasibility of inferring the RNA's intrinsic kinetic parameters from the noisy time series of the molecule's extension. A Bayesian approach using Monte Carlo Markov Chain is proposed. We prove that this statistical approach is efficient and accurate in inferring the molecule's physical parameters, even if the experimental data are yielded under a narrow range of forces.
资助者: Tsinghua Basic Research Foundation; National Science Foundation of China[10704045]
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000260533100003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/5440
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Xue, Xiao Chuan,Tong, Huan,Liu, Fei,et al. Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(44):13680-13683.
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